Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults

Matteo Bassetti, Elda Righi, Paola Del Giacomo, Assunta Sartor, Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Enrico Maria Trecarichi, Teresa Spanu, Chiara Paganino, Mario Tumbarello, Alessia Carnelutti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To analyze risk factors for early and late mortality in individuals aged 75 and older with Staphylococcus aureus bacteremia (SAB) in Italy. Design: Four-year retrospective observational study (January 2011-December 2014). Setting: Two tertiary care university hospitals in Italy (Santa Maria Misericordia Hospital in Udine, Policlinico Universitario Agostino Gemelli in Rome). Participants: All adults consecutively admitted with SAB. Measurements: Clinical presentation, infection characteristics, and clinical outcomes of individuals aged 75 and older were compared with those of individuals younger than 75. Results: Three hundred thirty-seven cases of SAB were diagnosed during the study period, 118 of which (35%) occurred in those aged 75 and older. Seven- (20.3% vs 9.2%) and 30-day (35.7% vs 20.7%) mortality were significantly higher in elderly than younger adults. Clinical presentation with septic shock, adequacy of empiric antibiotic treatment, and liver cirrhosis were found to be predictors of 7-day mortality in elderly adults with SAB. Risk factors independently associated with 30-day mortality included isolation of methicillin-resistant Staphylococcus aureus (MRSA) and not receiving an infectious disease consultation. Conclusion: Mortality is significantly higher in elderly than in younger adults with SAB, particularly in those presenting with septic shock, liver cirrhosis, or SAB due to MRSA. Additional risk factors for mortality included inappropriate empiric antibiotic treatment and not receiving an infectious disease consultation.

Original languageEnglish
Pages (from-to)1284-1289
Number of pages6
JournalJournal of the American Geriatrics Society
Volume66
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Bacteremia
Staphylococcus aureus
Mortality
Methicillin-Resistant Staphylococcus aureus
Septic Shock
Liver Cirrhosis
Italy
Communicable Diseases
Young Adult
Referral and Consultation
Anti-Bacterial Agents
Tertiary Healthcare
Observational Studies
Retrospective Studies
Therapeutics
Infection

Keywords

  • bacteremia
  • elderly
  • mortality
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Bassetti, M., Righi, E., Del Giacomo, P., Sartor, A., Ansaldi, F., Trucchi, C., ... Carnelutti, A. (2018). Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults. Journal of the American Geriatrics Society, 66(7), 1284-1289. https://doi.org/10.1111/jgs.15391

Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults. / Bassetti, Matteo; Righi, Elda; Del Giacomo, Paola; Sartor, Assunta; Ansaldi, Filippo; Trucchi, Cecilia; Alicino, Cristiano; Trecarichi, Enrico Maria; Spanu, Teresa; Paganino, Chiara; Tumbarello, Mario; Carnelutti, Alessia.

In: Journal of the American Geriatrics Society, Vol. 66, No. 7, 01.07.2018, p. 1284-1289.

Research output: Contribution to journalArticle

Bassetti, M, Righi, E, Del Giacomo, P, Sartor, A, Ansaldi, F, Trucchi, C, Alicino, C, Trecarichi, EM, Spanu, T, Paganino, C, Tumbarello, M & Carnelutti, A 2018, 'Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults', Journal of the American Geriatrics Society, vol. 66, no. 7, pp. 1284-1289. https://doi.org/10.1111/jgs.15391
Bassetti M, Righi E, Del Giacomo P, Sartor A, Ansaldi F, Trucchi C et al. Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults. Journal of the American Geriatrics Society. 2018 Jul 1;66(7):1284-1289. https://doi.org/10.1111/jgs.15391
Bassetti, Matteo ; Righi, Elda ; Del Giacomo, Paola ; Sartor, Assunta ; Ansaldi, Filippo ; Trucchi, Cecilia ; Alicino, Cristiano ; Trecarichi, Enrico Maria ; Spanu, Teresa ; Paganino, Chiara ; Tumbarello, Mario ; Carnelutti, Alessia. / Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults. In: Journal of the American Geriatrics Society. 2018 ; Vol. 66, No. 7. pp. 1284-1289.
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