Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes

A post hoc analysis of the SUR-VAPES 1 Study

Simona Mastrangeli, Roberto Carnevale, Elena Cavarretta, Sebastiano Sciarretta, Mariangela Peruzzi, Antonino G.M. Marullo, Elena De Falco, Isotta Chimenti, Valentina Valenti, Christopher Bullen, Leonardo Roever, Giacomo Frati, Giuseppe Biondi-Zoccai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.

Original languageEnglish
Article number18
JournalTobacco Induced Diseases
Volume16
Issue numberMay
DOIs
Publication statusPublished - May 1 2018

Fingerprint

nicotine
Tobacco
Blood Vessels
Oxidative Stress
Tobacco Products
smoking
electronics
Smoking
Dinoprost
Oral Contraceptives
Vitamin E
contraceptive
European Community
moderator
Biological Availability
Electronic Cigarettes
Dilatation
Nitric Oxide
Peptides
interaction

Keywords

  • Electronic cigarette
  • Endothelial dysfunction
  • Flow-mediated dilation
  • Oxidative stress
  • Smoking

ASJC Scopus subject areas

  • Health(social science)
  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health

Cite this

Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes : A post hoc analysis of the SUR-VAPES 1 Study. / Mastrangeli, Simona; Carnevale, Roberto; Cavarretta, Elena; Sciarretta, Sebastiano; Peruzzi, Mariangela; Marullo, Antonino G.M.; De Falco, Elena; Chimenti, Isotta; Valenti, Valentina; Bullen, Christopher; Roever, Leonardo; Frati, Giacomo; Biondi-Zoccai, Giuseppe.

In: Tobacco Induced Diseases, Vol. 16, No. May, 18, 01.05.2018.

Research output: Contribution to journalArticle

Mastrangeli, Simona ; Carnevale, Roberto ; Cavarretta, Elena ; Sciarretta, Sebastiano ; Peruzzi, Mariangela ; Marullo, Antonino G.M. ; De Falco, Elena ; Chimenti, Isotta ; Valenti, Valentina ; Bullen, Christopher ; Roever, Leonardo ; Frati, Giacomo ; Biondi-Zoccai, Giuseppe. / Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes : A post hoc analysis of the SUR-VAPES 1 Study. In: Tobacco Induced Diseases. 2018 ; Vol. 16, No. May.
@article{d325ccd022a64b76a875ca111fbefb7b,
title = "Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes: A post hoc analysis of the SUR-VAPES 1 Study",
abstract = "INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.",
keywords = "Electronic cigarette, Endothelial dysfunction, Flow-mediated dilation, Oxidative stress, Smoking",
author = "Simona Mastrangeli and Roberto Carnevale and Elena Cavarretta and Sebastiano Sciarretta and Mariangela Peruzzi and Marullo, {Antonino G.M.} and {De Falco}, Elena and Isotta Chimenti and Valentina Valenti and Christopher Bullen and Leonardo Roever and Giacomo Frati and Giuseppe Biondi-Zoccai",
year = "2018",
month = "5",
day = "1",
doi = "10.18332/tid/89975",
language = "English",
volume = "16",
journal = "Tobacco Induced Diseases",
issn = "1617-9625",
publisher = "BioMed Central",
number = "May",

}

TY - JOUR

T1 - Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes

T2 - A post hoc analysis of the SUR-VAPES 1 Study

AU - Mastrangeli, Simona

AU - Carnevale, Roberto

AU - Cavarretta, Elena

AU - Sciarretta, Sebastiano

AU - Peruzzi, Mariangela

AU - Marullo, Antonino G.M.

AU - De Falco, Elena

AU - Chimenti, Isotta

AU - Valenti, Valentina

AU - Bullen, Christopher

AU - Roever, Leonardo

AU - Frati, Giacomo

AU - Biondi-Zoccai, Giuseppe

PY - 2018/5/1

Y1 - 2018/5/1

N2 - INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.

AB - INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.

KW - Electronic cigarette

KW - Endothelial dysfunction

KW - Flow-mediated dilation

KW - Oxidative stress

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=85049849740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049849740&partnerID=8YFLogxK

U2 - 10.18332/tid/89975

DO - 10.18332/tid/89975

M3 - Article

VL - 16

JO - Tobacco Induced Diseases

JF - Tobacco Induced Diseases

SN - 1617-9625

IS - May

M1 - 18

ER -