Abstract
INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.
| Original language | English |
|---|---|
| Article number | 18 |
| Journal | Tobacco Induced Diseases |
| Volume | 16 |
| Issue number | May |
| DOIs | |
| Publication status | Published - May 1 2018 |
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Keywords
- Electronic cigarette
- Endothelial dysfunction
- Flow-mediated dilation
- Oxidative stress
- Smoking
ASJC Scopus subject areas
- Health(social science)
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
Cite this
Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes : A post hoc analysis of the SUR-VAPES 1 Study. / Mastrangeli, Simona; Carnevale, Roberto; Cavarretta, Elena; Sciarretta, Sebastiano; Peruzzi, Mariangela; Marullo, Antonino G.M.; De Falco, Elena; Chimenti, Isotta; Valenti, Valentina; Bullen, Christopher; Roever, Leonardo; Frati, Giacomo; Biondi-Zoccai, Giuseppe.
In: Tobacco Induced Diseases, Vol. 16, No. May, 18, 01.05.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes
T2 - A post hoc analysis of the SUR-VAPES 1 Study
AU - Mastrangeli, Simona
AU - Carnevale, Roberto
AU - Cavarretta, Elena
AU - Sciarretta, Sebastiano
AU - Peruzzi, Mariangela
AU - Marullo, Antonino G.M.
AU - De Falco, Elena
AU - Chimenti, Isotta
AU - Valenti, Valentina
AU - Bullen, Christopher
AU - Roever, Leonardo
AU - Frati, Giacomo
AU - Biondi-Zoccai, Giuseppe
PY - 2018/5/1
Y1 - 2018/5/1
N2 - INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.
AB - INTRODUCTION Use of a conventional cigarette (CC) or electronic cigarette (EC) leads to oxidative stress and endothelial dysfunction, but the impact of other features and their interplay with CCs and ECs have been incompletely appraised. We explored moderators of CC and EC effects on oxidative stress and endothelial dysfunction. METHODS We have conducted an experimental study on CCs and ECs in which repeated indicators of oxidative stress (serum levels of soluble NOX2-derived peptide, nitric oxide bioavailability, 8-iso-prostaglandin F2α-III, and vitamin E) and endothelial dysfunction (flow-mediated dilation) were collected in 40 subjects (20 smokers, 20 non-smokers). Several moderating features were appraised, adjusting for smoking status and cigarette type. RESULTS Absolute changes in oxidative stress and vascular features after smoking a CC or vaping an EC were significantly correlated (all p<0.05), with the notable exception of 8-iso-prostaglandin F2α-III levels (p=0.030). Inferential analysis based on generalized estimating equations highlighted that the only variable significantly associated with oxidative stress and vascular features was smoking status (all p<0.05). Specifically, we found that smokers had a less pronounced untoward oxidative and vascular response after vaping an EC in comparison to non-smokers, who had oxidative and vascular reactions to an EC that resembled more those seen after smoking a CC. Intriguingly, women taking oral contraceptives appeared to have more unfavorable changes in vitamin E (p=0.002) and FMD (p=0.008). CONCLUSIONS This study suggests that the comparative oxidative and vascular effects of an EC versus a CC may be influenced by smoking status, with a potential interaction in women taking oral contraceptives. These findings need further confirmation but could have important clinical and policy implications.
KW - Electronic cigarette
KW - Endothelial dysfunction
KW - Flow-mediated dilation
KW - Oxidative stress
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=85049849740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049849740&partnerID=8YFLogxK
U2 - 10.18332/tid/89975
DO - 10.18332/tid/89975
M3 - Article
AN - SCOPUS:85049849740
VL - 16
JO - Tobacco Induced Diseases
JF - Tobacco Induced Diseases
SN - 1617-9625
IS - May
M1 - 18
ER -