Abstract
Original language | English |
---|---|
Pages (from-to) | 52-62 |
Number of pages | 11 |
Journal | Dysphagia |
Volume | 34 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Human papilloma virus
- Long-term dysphagia
- MDADI score
- Oropharyngeal carcinoma
- Xerostomia
- adult
- Article
- cancer chemotherapy
- clinical evaluation
- cross-sectional study
- disease association
- dysphagia
- female
- follow up
- gender
- human
- induction chemotherapy
- intensity modulated radiation therapy
- major clinical study
- male
- oropharynx cancer
- Papillomaviridae
- patient-reported outcome
- priority journal
- questionnaire
- xerostomia
- aged
- chemoradiotherapy
- evaluation study
- middle aged
- multivariate analysis
- oropharynx tumor
- radiation injury
- risk factor
- sex factor
- Aged
- Chemoradiotherapy
- Cross-Sectional Studies
- Deglutition Disorders
- Female
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Oropharyngeal Neoplasms
- Patient Reported Outcome Measures
- Radiation Injuries
- Radiotherapy, Intensity-Modulated
- Risk Factors
- Sex Factors
- Surveys and Questionnaires
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Predictors of Patient-Reported Dysphagia Following IMRT Plus Chemotherapy in Oropharyngeal Cancer. / Orlandi, E.; Miceli, R.; Infante, G. et al.
In: Dysphagia, Vol. 34, No. 1, 2019, p. 52-62.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Predictors of Patient-Reported Dysphagia Following IMRT Plus Chemotherapy in Oropharyngeal Cancer
AU - Orlandi, E.
AU - Miceli, R.
AU - Infante, G.
AU - Mirabile, A.
AU - Alterio, D.
AU - Cossu Rocca, M.
AU - Denaro, N.
AU - Vigna-Taglianti, R.
AU - Merlotti, A.
AU - Schindler, A.
AU - Pizzorni, N.
AU - Fallai, C.
AU - Licitra, L.
AU - Bossi, P.
N1 - Export Date: 28 February 2020 CODEN: DYSPE Correspondence Address: Orlandi, E.; Radiotherapy 2 Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian, 1, Italy; email: ester.orlandi@istitutotumori.mi.it References: Caudell, J.J., Schaner, P.E., Meredith, R.F., Locher, J.L., Nabell, L.M., Carroll, W.R., Magnuson, J.S., Bonner, J.A., Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer (2009) Int J Radiat Oncol Biol Phys, 73, pp. 410-415; Trotti, A., Colevas, A.D., Setser, A., Basch, E., Patient-reported outcomes and the evolution of adverse event reporting in oncology (2007) J Clin Oncol, 25, pp. 5121-5127; Russi, E.G., Corvò, R., Merlotti, A., Alterio, D., Franco, P., Pergolizzi, S., De Sanctis, V., Bernier, J., Swallowing dysfunction in head and neck cancer patients treated by radiotherapy: review and recommendations of the supportive task group of the Italian Association of Radiation Oncology (2012) Cancer Treat Rev, 38, pp. 1033-1049; Nguyen, N.P., Moltz, C.C., Frank, C., Vos, P., Smith, H.J., Karlsson, U., Nguyen, L.M., Sallah, S., Evolution of chronic dysphagia following treatment for head and neck cancer (2006) Oral Oncol, 42, pp. 374-380; Langendijk, J.A., Doornaert, P., Verdonck-de Leeuw, I.M., Leemans, C.R., Aaronson, N.K., Slotman, B.J., Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy (2008) J Clin Oncol, 26, pp. 3770-3776; Hunter, K.U., Schipper, M., Feng, F.Y., Lyden, T., Haxer, M., Murdoch-Kinch, C.A., Cornwall, B., Eisbruch, A., Toxicities affecting quality of life after chemo-IMRT of oropharyngeal cancer: prospective study of patient-reported, observer-rated, and objective outcomes (2013) Int J Radiat Oncol Biol Phys, 85, pp. 935-940; Al-Mamgani, A., Mehilal, R., van Rooij, P.H., Tans, L., Sewnaik, A., Levendag, P.C., Toxicity, quality of life, and functional outcomes of 176 hypopharyngeal cancer patients treated by (chemo)radiation: the impact of treatment modality and radiation technique (2012) Laryngoscope, 122, pp. 1789-1795; Ramaekers, B.L., Joore, M.A., Grutters, J.P., van den Ende, P., Jong, J., Houben, R., Lambin, P., Langendijk, J.A., The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy (2011) Oral Oncol, 47, pp. 768-774; Feng, F.Y., Kim, H.M., Lyden, T.H., Haxer, M.J., Worden, F.P., Feng, M., Moyer, J.S., Eisbruch, A., Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results (2010) J Clin Oncol, 28, pp. 2732-2738; Eisbruch, A., Kim, H.M., Feng, F.Y., Haxer, M.J., Feng, M., Worden, F.P., Bradford, C.R., Ten Haken, R.K., Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates (2011) Int J Radiat Oncol Biol Phys, 81, pp. e93-e99; Maxwell, J.H., Mehta, V., Wang, H., Cunningham, D., Duvvuri, U., Kim, S., Johnson, J.T., Ferris, R.L., Quality of life in head and neck cancer patients: impact of HPV and primary treatment modality (2014) Laryngoscope, 124, pp. 1592-1597; Rogers, S.N., Barber, B., Using PROMs to guide patients and practitioners through the head and neck cancer journey (2017) Patient Relat Outcome Meas, 8, pp. 133-142; Jensen, S.B., Pedersen, A.M., Vissink, A., Andersen, E., Brown, C.G., Davies, A.N., Dutilh, J., Brennan, M.T., A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life (2010) Support Care Cancer, 18, pp. 1039-1060; Pedersen, A., Wilson, J., McColl, E., Carding, P., Patterson, J., Swallowing outcome measures in head and neck cancer–How do they compare? 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PY - 2019
Y1 - 2019
N2 - The aim of this cross-sectional study is to evaluate the factors associated with patient-reported dysphagia in patients affected by locally advanced oropharyngeal cancer (OPC) treated with definitive intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy (CHT), with or without induction CHT. We evaluated 148 OPC patients treated with IMRT and concurrent CHT, without evidence of disease and who had completed their treatment since at least 6 months. At their planned follow-up visit, patients underwent clinical evaluation and completed the M.D. Anderson dysphagia inventory (MDADI) questionnaire. The association between questionnaire composite score (MDADI-CS) and different patients’ and tumor’s characteristics and treatments (covariates) was investigated by univariable and multivariable analyses, the latter including only covariates significant at univariable analysis. With a median time from treatment end of 30 months [range 6–74 months, interquartile range (IQR) 16–50 months], the median (IQR) MDADI-CS was 72 (63–84). The majority of patients (82.4%) had a MDADI-CS ≥ 60. At multivariable analysis, female gender, human papilloma virus (HPV)-negative status, and moderate and severe clinician-rated xerostomia were significantly associated with lower MDADI-CS. Patient-perceived dysphagia was satisfactory or acceptable in the majority of patients. HPV status and xerostomia were confirmed as important predictive factors for swallowing dysfunction after radiochemotherapy. Data regarding female gender are new and deserve further investigation. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
AB - The aim of this cross-sectional study is to evaluate the factors associated with patient-reported dysphagia in patients affected by locally advanced oropharyngeal cancer (OPC) treated with definitive intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy (CHT), with or without induction CHT. We evaluated 148 OPC patients treated with IMRT and concurrent CHT, without evidence of disease and who had completed their treatment since at least 6 months. At their planned follow-up visit, patients underwent clinical evaluation and completed the M.D. Anderson dysphagia inventory (MDADI) questionnaire. The association between questionnaire composite score (MDADI-CS) and different patients’ and tumor’s characteristics and treatments (covariates) was investigated by univariable and multivariable analyses, the latter including only covariates significant at univariable analysis. With a median time from treatment end of 30 months [range 6–74 months, interquartile range (IQR) 16–50 months], the median (IQR) MDADI-CS was 72 (63–84). The majority of patients (82.4%) had a MDADI-CS ≥ 60. At multivariable analysis, female gender, human papilloma virus (HPV)-negative status, and moderate and severe clinician-rated xerostomia were significantly associated with lower MDADI-CS. Patient-perceived dysphagia was satisfactory or acceptable in the majority of patients. HPV status and xerostomia were confirmed as important predictive factors for swallowing dysfunction after radiochemotherapy. Data regarding female gender are new and deserve further investigation. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
KW - Human papilloma virus
KW - Long-term dysphagia
KW - MDADI score
KW - Oropharyngeal carcinoma
KW - Xerostomia
KW - adult
KW - Article
KW - cancer chemotherapy
KW - clinical evaluation
KW - cross-sectional study
KW - disease association
KW - dysphagia
KW - female
KW - follow up
KW - gender
KW - human
KW - induction chemotherapy
KW - intensity modulated radiation therapy
KW - major clinical study
KW - male
KW - oropharynx cancer
KW - Papillomaviridae
KW - patient-reported outcome
KW - priority journal
KW - questionnaire
KW - xerostomia
KW - aged
KW - chemoradiotherapy
KW - evaluation study
KW - middle aged
KW - multivariate analysis
KW - oropharynx tumor
KW - radiation injury
KW - risk factor
KW - sex factor
KW - Aged
KW - Chemoradiotherapy
KW - Cross-Sectional Studies
KW - Deglutition Disorders
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Oropharyngeal Neoplasms
KW - Patient Reported Outcome Measures
KW - Radiation Injuries
KW - Radiotherapy, Intensity-Modulated
KW - Risk Factors
KW - Sex Factors
KW - Surveys and Questionnaires
U2 - 10.1007/s00455-018-9913-8
DO - 10.1007/s00455-018-9913-8
M3 - Article
VL - 34
SP - 52
EP - 62
JO - Dysphagia
JF - Dysphagia
SN - 0179-051X
IS - 1
ER -