Predictors of psychopathological outcome during peg-interferon and ribavirin therapy in patients with chronic HCV-correlated hepatitis

Bernardo Dell'Osso, Gianmaria Prati, M. Carlotta Palazzo, Maria Grazia Rumi, Flaminia Cavallaro, Alessio Aghemo, Massimo Colombo, A. Carlo Altamura

Research output: Contribution to journalArticlepeer-review

Abstract

Peg-interferon (Peg-IFN) and ribavirin (RBV) therapy is reported to induce psychiatric symptoms and syndromes in 20% of patients treated for Hepatitis C Virus (HCV) infection. Present study was aimed to quantify the phenomenon and assess the influence of psychiatric counseling over antiviral completion rate and the use of psychometric tools, in terms of prediction of psychopathological outcome. Ninety-six HCV patients were assessed, before antiviral treatment, by means of the Sheehan Disability Scale (SDS), Mood Disorder Questionnaire (MDQ), Symptom Checklist-90, and Internal State Scale (ISS). Sociodemographic and clinical variables and completion rate were collected. Binary logistic regression was performed to evaluate whether scores were predictive of psychiatric visit, development of psychiatric disorders, and need for treatment. Ninety-five patients (99%) completed antiviral treatment; 27 subjects (29%) needed psychiatric visit: among them, mood disorder was diagnosed in 15 (16%) and were pharmacologically treated. Baseline SDS and MDQ higher scores were found to be predictive of psychiatric visit [odds ratio (OR)=1.258, P

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Cell Biology

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