Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer

Matteo Ferro, Giuseppe Di Lorenzo, Carlo Buonerba, Giuseppe Lucarelli, Giorgio Ivan Russo, Francesco Cantiello, Abdal Rahman Abu Farhan, Savino Di Stasi, Gennaro Musi, Rodolfo Hurle, Serretta Vincenzo, Gian Maria Busetto, Ettore De Berardinis, Sisto Perdonà, Marco Borghesi, Riccardo Schiavina, Gilberto L. Almeida, Pierluigi Bove, Estevao Lima, Giovanni Grimaldi & 15 others Deliu Victor Matei, Francesco Alessandro Mistretta, Nicolae Crisan, Daniela Terracciano, Verze Paolo, Michele Battaglia, Giorgio Guazzoni, Riccardo Autorino, Giuseppe Morgia, Rocco Damiano, Matteo Muto, Roberto La Rocca, Vincenzo Mirone, Ottavio De Cobelli, Mihai Dorin Vartolomei

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Abstract

The aim of this multi-institutional study was to identify predictors of residual high-grade (HG) disease at re-transurethral resection (reTUR) in a large cohort of primary T1 HG/Grade 3 (G3) bladder cancer patients. A total of 1155 patients with primary T1 HG/G3 bladder cancer from 13 academic institutions that underwent a reTUR within 6 weeks after first TUR were evaluated. Logistic regression analysis was performed to assess the association of predictive factors with residual HG at reTUR. Residual HG cancer was found in 288 (24.9%) of patients at reTUR. Patients presenting residual HG cancer were more likely to have carcinoma in situ (CIS) at first resection (p<0.001), multiple tumors (p=0.02), and tumor size larger than 3 cm (p=0.02). Residual HG disease at reTUR was associated with increased preoperative neutrophil-to-lymphocytes ratio (NLR) (p=0.006) and body mass index (BMI)>=25 kg/m2. On multivariable analysis, independent predictors for HG residual disease at reTUR were tumor size >3cm (OR = 1.37; 95% CI: 1.02-1.84, p=0.03), concomitant CIS (OR 1.92; 95% CI: 1.32-2.78, p=0.001), being overweight (OR= 2.08; 95% CI: 1.44-3.01, p<0.001) and obesity (OR 2.48; 95% CI: 1.64-3.77, p<0.001). A reTUR in high grade T1 bladder cancer is mandatory as about 25% of patients, presents residual high grade disease. Independent predictors to identify patients at risk of residual high grade disease after a complete TUR include tumor size, presence of carcinoma in situ, and BMI >=25 kg/m2.

Original languageEnglish
Pages (from-to)4250-4254
Number of pages5
JournalJournal of Cancer
Volume9
Issue number22
DOIs
Publication statusPublished - Jan 1 2018

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Urinary Bladder Neoplasms
Carcinoma in Situ
Neoplasms
Logistic Models
Regression Analysis

Keywords

  • Bladder cancer
  • High-grade
  • Neutrophil-to-lymphocytes ratio
  • Re-transurethral resection

ASJC Scopus subject areas

  • Oncology

Cite this

Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer. / Ferro, Matteo; Lorenzo, Giuseppe Di; Buonerba, Carlo; Lucarelli, Giuseppe; Russo, Giorgio Ivan; Cantiello, Francesco; Farhan, Abdal Rahman Abu; Stasi, Savino Di; Musi, Gennaro; Hurle, Rodolfo; Vincenzo, Serretta; Busetto, Gian Maria; De Berardinis, Ettore; Perdonà, Sisto; Borghesi, Marco; Schiavina, Riccardo; Almeida, Gilberto L.; Bove, Pierluigi; Lima, Estevao; Grimaldi, Giovanni; Matei, Deliu Victor; Mistretta, Francesco Alessandro; Crisan, Nicolae; Terracciano, Daniela; Paolo, Verze; Battaglia, Michele; Guazzoni, Giorgio; Autorino, Riccardo; Morgia, Giuseppe; Damiano, Rocco; Muto, Matteo; Rocca, Roberto La; Mirone, Vincenzo; De Cobelli, Ottavio; Vartolomei, Mihai Dorin.

In: Journal of Cancer, Vol. 9, No. 22, 01.01.2018, p. 4250-4254.

Research output: Contribution to journalArticle

Ferro, M, Lorenzo, GD, Buonerba, C, Lucarelli, G, Russo, GI, Cantiello, F, Farhan, ARA, Stasi, SD, Musi, G, Hurle, R, Vincenzo, S, Busetto, GM, De Berardinis, E, Perdonà, S, Borghesi, M, Schiavina, R, Almeida, GL, Bove, P, Lima, E, Grimaldi, G, Matei, DV, Mistretta, FA, Crisan, N, Terracciano, D, Paolo, V, Battaglia, M, Guazzoni, G, Autorino, R, Morgia, G, Damiano, R, Muto, M, Rocca, RL, Mirone, V, De Cobelli, O & Vartolomei, MD 2018, 'Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer', Journal of Cancer, vol. 9, no. 22, pp. 4250-4254. https://doi.org/10.7150/jca.26129
Ferro, Matteo ; Lorenzo, Giuseppe Di ; Buonerba, Carlo ; Lucarelli, Giuseppe ; Russo, Giorgio Ivan ; Cantiello, Francesco ; Farhan, Abdal Rahman Abu ; Stasi, Savino Di ; Musi, Gennaro ; Hurle, Rodolfo ; Vincenzo, Serretta ; Busetto, Gian Maria ; De Berardinis, Ettore ; Perdonà, Sisto ; Borghesi, Marco ; Schiavina, Riccardo ; Almeida, Gilberto L. ; Bove, Pierluigi ; Lima, Estevao ; Grimaldi, Giovanni ; Matei, Deliu Victor ; Mistretta, Francesco Alessandro ; Crisan, Nicolae ; Terracciano, Daniela ; Paolo, Verze ; Battaglia, Michele ; Guazzoni, Giorgio ; Autorino, Riccardo ; Morgia, Giuseppe ; Damiano, Rocco ; Muto, Matteo ; Rocca, Roberto La ; Mirone, Vincenzo ; De Cobelli, Ottavio ; Vartolomei, Mihai Dorin. / Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer. In: Journal of Cancer. 2018 ; Vol. 9, No. 22. pp. 4250-4254.
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T1 - Predictors of residual T1 high grade on re-transurethral resection in a large multi-institutional cohort of patients with primary T1 high-grade/grade 3 bladder cancer

AU - Ferro, Matteo

AU - Lorenzo, Giuseppe Di

AU - Buonerba, Carlo

AU - Lucarelli, Giuseppe

AU - Russo, Giorgio Ivan

AU - Cantiello, Francesco

AU - Farhan, Abdal Rahman Abu

AU - Stasi, Savino Di

AU - Musi, Gennaro

AU - Hurle, Rodolfo

AU - Vincenzo, Serretta

AU - Busetto, Gian Maria

AU - De Berardinis, Ettore

AU - Perdonà, Sisto

AU - Borghesi, Marco

AU - Schiavina, Riccardo

AU - Almeida, Gilberto L.

AU - Bove, Pierluigi

AU - Lima, Estevao

AU - Grimaldi, Giovanni

AU - Matei, Deliu Victor

AU - Mistretta, Francesco Alessandro

AU - Crisan, Nicolae

AU - Terracciano, Daniela

AU - Paolo, Verze

AU - Battaglia, Michele

AU - Guazzoni, Giorgio

AU - Autorino, Riccardo

AU - Morgia, Giuseppe

AU - Damiano, Rocco

AU - Muto, Matteo

AU - Rocca, Roberto La

AU - Mirone, Vincenzo

AU - De Cobelli, Ottavio

AU - Vartolomei, Mihai Dorin

PY - 2018/1/1

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N2 - The aim of this multi-institutional study was to identify predictors of residual high-grade (HG) disease at re-transurethral resection (reTUR) in a large cohort of primary T1 HG/Grade 3 (G3) bladder cancer patients. A total of 1155 patients with primary T1 HG/G3 bladder cancer from 13 academic institutions that underwent a reTUR within 6 weeks after first TUR were evaluated. Logistic regression analysis was performed to assess the association of predictive factors with residual HG at reTUR. Residual HG cancer was found in 288 (24.9%) of patients at reTUR. Patients presenting residual HG cancer were more likely to have carcinoma in situ (CIS) at first resection (p<0.001), multiple tumors (p=0.02), and tumor size larger than 3 cm (p=0.02). Residual HG disease at reTUR was associated with increased preoperative neutrophil-to-lymphocytes ratio (NLR) (p=0.006) and body mass index (BMI)>=25 kg/m2. On multivariable analysis, independent predictors for HG residual disease at reTUR were tumor size >3cm (OR = 1.37; 95% CI: 1.02-1.84, p=0.03), concomitant CIS (OR 1.92; 95% CI: 1.32-2.78, p=0.001), being overweight (OR= 2.08; 95% CI: 1.44-3.01, p<0.001) and obesity (OR 2.48; 95% CI: 1.64-3.77, p<0.001). A reTUR in high grade T1 bladder cancer is mandatory as about 25% of patients, presents residual high grade disease. Independent predictors to identify patients at risk of residual high grade disease after a complete TUR include tumor size, presence of carcinoma in situ, and BMI >=25 kg/m2.

AB - The aim of this multi-institutional study was to identify predictors of residual high-grade (HG) disease at re-transurethral resection (reTUR) in a large cohort of primary T1 HG/Grade 3 (G3) bladder cancer patients. A total of 1155 patients with primary T1 HG/G3 bladder cancer from 13 academic institutions that underwent a reTUR within 6 weeks after first TUR were evaluated. Logistic regression analysis was performed to assess the association of predictive factors with residual HG at reTUR. Residual HG cancer was found in 288 (24.9%) of patients at reTUR. Patients presenting residual HG cancer were more likely to have carcinoma in situ (CIS) at first resection (p<0.001), multiple tumors (p=0.02), and tumor size larger than 3 cm (p=0.02). Residual HG disease at reTUR was associated with increased preoperative neutrophil-to-lymphocytes ratio (NLR) (p=0.006) and body mass index (BMI)>=25 kg/m2. On multivariable analysis, independent predictors for HG residual disease at reTUR were tumor size >3cm (OR = 1.37; 95% CI: 1.02-1.84, p=0.03), concomitant CIS (OR 1.92; 95% CI: 1.32-2.78, p=0.001), being overweight (OR= 2.08; 95% CI: 1.44-3.01, p<0.001) and obesity (OR 2.48; 95% CI: 1.64-3.77, p<0.001). A reTUR in high grade T1 bladder cancer is mandatory as about 25% of patients, presents residual high grade disease. Independent predictors to identify patients at risk of residual high grade disease after a complete TUR include tumor size, presence of carcinoma in situ, and BMI >=25 kg/m2.

KW - Bladder cancer

KW - High-grade

KW - Neutrophil-to-lymphocytes ratio

KW - Re-transurethral resection

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