Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores

Fabiola Atzeni; Sara Bongiovanni; Antonio Marchesoni; Matteo Filippini; Roberto Caporali; Roberto Gorla; Lorenzo Cavagna; Ennio Giulio Favalli; Francesco Saccardo; Piercarlo Sarzi-Puttini

doi:10.1016/j.jbspin.2013.04.005

Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores

Fabiola Atzeni, Sara Bongiovanni, Antonio Marchesoni, Matteo Filippini, Roberto Caporali, Roberto Gorla, Lorenzo Cavagna, Ennio Giulio Favalli, Francesco Saccardo, Piercarlo Sarzi-Puttini

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5. years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28scores (moderate. >. 3.2-5.1 [MDA] and high. >. 5.1 [HDA]). Methods: Disease activity at baseline and after 12. months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria. Results: The study involved 1300patients with established RA: 975 with HDA and 325with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Joint Bone Spine
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/j.jbspin.2013.04.005
Publication status	Published - Jan 2014

Keywords

Anti-TNF
DAS28 scores
High and moderate disease activity
Predictive factors

ASJC Scopus subject areas

Rheumatology

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10.1016/j.jbspin.2013.04.005

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title = "Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores",

abstract = "Objectives: To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5. years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28scores (moderate. >. 3.2-5.1 [MDA] and high. >. 5.1 [HDA]). Methods: Disease activity at baseline and after 12. months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria. Results: The study involved 1300patients with established RA: 975 with HDA and 325with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P",

keywords = "Anti-TNF, DAS28 scores, High and moderate disease activity, Predictive factors",

author = "Fabiola Atzeni and Sara Bongiovanni and Antonio Marchesoni and Matteo Filippini and Roberto Caporali and Roberto Gorla and Lorenzo Cavagna and Favalli, {Ennio Giulio} and Francesco Saccardo and Piercarlo Sarzi-Puttini",

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month = jan,

doi = "10.1016/j.jbspin.2013.04.005",

language = "English",

volume = "81",

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T1 - Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores

AU - Atzeni, Fabiola

AU - Bongiovanni, Sara

AU - Marchesoni, Antonio

AU - Filippini, Matteo

AU - Caporali, Roberto

AU - Gorla, Roberto

AU - Cavagna, Lorenzo

AU - Favalli, Ennio Giulio

AU - Saccardo, Francesco

AU - Sarzi-Puttini, Piercarlo

PY - 2014/1

Y1 - 2014/1

N2 - Objectives: To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5. years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28scores (moderate. >. 3.2-5.1 [MDA] and high. >. 5.1 [HDA]). Methods: Disease activity at baseline and after 12. months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria. Results: The study involved 1300patients with established RA: 975 with HDA and 325with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P

AB - Objectives: To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5. years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28scores (moderate. >. 3.2-5.1 [MDA] and high. >. 5.1 [HDA]). Methods: Disease activity at baseline and after 12. months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria. Results: The study involved 1300patients with established RA: 975 with HDA and 325with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P

KW - Anti-TNF

KW - DAS28 scores

KW - High and moderate disease activity

KW - Predictive factors

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Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores

Abstract

Keywords

ASJC Scopus subject areas

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