Predictors of response to cardiac resynchronization therapy (PROSPECT) - Study design

Cheuk Man Yu, William T. Abraham, Jeroen Bax, Eugene Chung, Michelle Fedewa, Stefano Ghio, Christophe Leclercq, Angel R. León, John Merlino, Petros Nihoyannopoulos, Dean Notabartolo, Jing Ping Sun, Luigi Tavazzi

Research output: Contribution to journalArticlepeer-review


Background: Cardiac resynchronization therapy (CRT) is currently indicated in patients with moderate to severe heart failure, a wide QRS complex and significant left ventricular dysfunction despite optimal medical therapy. Adoption of these criteria for CRT results in a favorable response in only two thirds of candidates. Methods: "Predictors of response to cardiac resynchronization therapy (PROSPECT)," a prospective, multicenter, nonrandomized study, aims to identify echocardiographic measures of dyssynchrony and evaluate their ability to predict response to CRT. PROSPECT will enroll approximately 300 patients in up to 75 centers in the United States, Asia, and Europe with clinical follow-up for 6 months. We will prospectively and individually test a variety of conventional echocardiographic and tissue Doppler imaging parameters against measures of clinical response. The primary response criteria are improvement in the heart failure Clinical Composite Score and left ventricular reverse remodeling. Enrollment began in March 2004 and is expected to conclude early 2005.

Original languageEnglish
Pages (from-to)600-605
Number of pages6
JournalAmerican Heart Journal
Issue number4
Publication statusPublished - Apr 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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