Predictors of Successful Oxygen Weaning in Older Patients Undergoing Pulmonary Rehabilitation

Tiziano Nestola, Laura Orlandini, Antonella Ferrari, Valter Monzani, Giorgio Gallimbeni, Luigi C. Bergamaschini, Matteo Cesari

Research output: Contribution to journalArticlepeer-review


Objectives: To identify clinical and/or functional variables predictive of successful oxygen-weaning among older patients affected by respiratory insufficiency undergoing pulmonary rehabilitation. Design: Retrospective study. Setting and Participants: Data are from 154 patients aged 65 years and older (mean age = 78.1 years; female 50.6%) admitted to a pulmonary rehabilitation unit to follow an in-patient program. Patients must require oxygen therapy at admission. Methods: All patients performed the 6-Minute Walking Test at admission and before discharge as well as a spirometry at a steady state. Multivariate logistic regressions were performed to identify positive and negative predictors of successful oxygen weaning. Results: Successful oxygen weaning was obtained in 47 participants (30.5%). The restrictive pattern was associated with a 4-fold likelihood of successful oxygen weaning at the end of the rehabilitation program compared with the obstructive one. A positive association was also found for arterial oxygenation index (PaO2/FiO2 ratio) at baseline. A decreased likelihood of successful oxygen weaning was reported for the subjective dyspnea perception score at exertion evaluated with a modified Borg scale. Conclusions and Implications: The restrictive pattern, PaO2/FiO2 ratio, and modified Borg dyspnea scale score under exertion were significantly associated with successful oxygen-weaning. The identified predictors may support clinicians at precociously identifying patients who may not require oxygen therapy after discharge. Therefore, these findings would make it possible for clinicians to better tailor the rehabilitation program.

Original languageEnglish
Pages (from-to):1153-1156
JournalJournal of the American Medical Directors Association
Issue number8
Publication statusPublished - 2020


  • Elderly
  • oxygen weaning
  • predictors
  • pulmonary rehabilitation

ASJC Scopus subject areas

  • Nursing(all)
  • Health Policy
  • Geriatrics and Gerontology


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