Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy

Antonella Antenora, Dario Bruzzese, Maria Lieto, Alessandro Roca, Maria Teresa Florio, Silvio Peluso, Francesco Saccà, Giuseppe De Michele, Filippo Maria Santorelli, Alessandro Filla

Research output: Contribution to journalArticle

Abstract

One hundred-eighteen spinocerebellar ataxia type 2 patients from 35 distinct families personally observed between 1973 and 2016 were retrospectively reviewed. The time point of data collection was 1 January 2017. Thirty-one patients were confined to wheelchair. The median time to wheelchair was 21 years (95% CI, 17.5–24.6). Thirty-seven patients were deceased. The median time to death was 25 years (95% CI, 22.9–27.1). CAG repeat number and ataxia score at first visit influenced the time to wheelchair and death.

Original languageEnglish
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Ataxia scale
  • CAG repeats
  • SCA2
  • Survival

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Antenora, A., Bruzzese, D., Lieto, M., Roca, A., Florio, M. T., Peluso, S., Saccà, F., De Michele, G., Santorelli, F. M., & Filla, A. (Accepted/In press). Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy. Neurological Sciences. https://doi.org/10.1007/s10072-018-3504-1