Predictors of the early impairment of renal disease in human obesity

L. Gilardini, A. Zulian, A. Girola, G. Redaelli, A. Conti, C. Invitti

Research output: Contribution to journalArticle

Abstract

Objective: The mechanisms underlying the association of the increased albumin excretion rate (AER) with adiposity have yet to be clarified. We therefore investigated (1) the predictors of AER after 3 months of lifestyle intervention in a large cohort of nondiabetic obese women and (2) the relationships between AER and the adipose tissue gene expression of adipokines linked to inflammation and insulin resistance.Subjects: A total of 269 obese nondiabetic women (age 49.913.1 years, body mass index (BMI) 36.84.6 kg m 2) participated in this program. Measurements used were anthropometrics parameters, blood pressure, oral glucose tolerance test, lipids, creatinine, AER, homeostasis model assessment of insulin resistance (HOMA-IR) and glomerular filtration rate at baseline and after 3 months of lifestyle intervention. At baseline, in a subgroup of 34 women, subcutaneous adipose tissue biopsy was carried out for the analysis of mRNA expression levels of adiponectin, suppressor of cytokine signaling 3 (SOCS-3), tumor necrosis factor α (TNF-α), pentraxine 3 (PTX-3), angiotensinogen and angiotensin-converting enzyme, and a blood sample was also taken from this group for the measurement of circulating adiponectin, interleukin-6, TNF-α and PTX-3. Microalbuminuria was defined as albumin/creatinine ratio 3.5 mg mmol 1. Real-time PCR was used to quantify mRNA.Results: Six percent of obese women had microalbuminuria. When dividing the whole cohort into three groups according to AER changes (decrease, stability and increase), we noted that 2 h glucose, insulin and HOMA-IR significantly decreased (P

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalInternational Journal of Obesity
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2010

    Fingerprint

Keywords

  • Adipose tissue
  • Glucose homeostasis
  • Microalbuminuria
  • PTX-3
  • SOCS-3
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this