Prednisone administration in recent onset type I diabetes

Antonio Secchi, Matteo R. Pastore, Alessandro Sergi, Antonio E. Pontiroli, Guido Pozza

Research output: Contribution to journalArticlepeer-review


The aim of our study was to investigate the efficacy of prednisone to preserve pancreatic β-cell function in patients with recent-onset Type I diabetes mellitus (IDDM). Twenty-five patients with IDDM, aged 24±6 years, entered the trial within 8 weeks of the onset of diabetes. They were allocated, according to a single blind randomized protocol, to one of the following treatments: (A) prednisone (15 mg/day), (B) indomethacin (100 mg/day), (C) placebo. All treatments lasted 8 months and all patients achieved satisfactory metabolic control with a multi-injection regimen (three injections/day) within a few weeks, and maintained it throughout the entire period of observation. Only minor side effects were observed in the prednisone-treated patients. A lower insulin requirement was observed in the prednisone group than in other patients at 12 months (0·33±0·11 vs 0·57±0·06 U/kg/day, P

Original languageEnglish
Pages (from-to)593-600
Number of pages8
JournalJournal of Autoimmunity
Issue number5
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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