Prednisone, indomethacin, or theophylline administration and the remission phase in recent onset type I insulin-dependent diabetic patients

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Abstract

The growing evidence of the role of the cellular and humoral immunity in the pathogenesis of type I, insulin-dependent diabetes mellitus has led many authors to try various immunomodulating treatments at the onset of the disease, both in animals and in man. No definitive conclusions have been achieved, although some major immunosuppressive agents, ie, Cyclosporine or Azathioprine, gave promising results in these patients. The aim of our study was to evaluate the efficacy of Prednisone or Theophylline to induce remissions in recent onset type I diabetic patients. Each of these drugs was studied through a control v placebo, single-blind, protocol. In the case of Prednisone, a further control consisted of Indomethacin administration, in order to determine whether any effect of Prednisone was related to its antiinflammatory or immunosuppressive action.

Original languageEnglish
Pages (from-to)1540-1542
Number of pages3
JournalTransplantation Proceedings
Volume18
Issue number6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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