Predominant expression of σ and ε globin genes in human leukemia K-562(S6) variant cell line

R. Gambari; G. Raschellà; R. Biagini; M. Tripodi; M. G. Farace; A. Romeo; A. Fantoni

doi:10.1007/BF01963156

Predominant expression of σ and ε globin genes in human leukemia K-562(S6) variant cell line

R. Gambari, G. Raschellà, R. Biagini, M. Tripodi, M. G. Farace, A. Romeo, A. Fantoni

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

In the human leukemia K-562(S6) cell line (a) the accumulation of a-globin chains is low or absent, (b) ζ-globin gene expression is correlated with expression of ε-chains and (c) the genes responsible for the terminal cell division are not operated within 8-12 cell cycles, while K-562 (S6) cells are fully induced to erythroid differentiation.

Original language	English
Pages (from-to)	415-416
Number of pages	2
Journal	Experientia
Volume	39
Issue number	4
DOIs	https://doi.org/10.1007/BF01963156
Publication status	Published - 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01963156

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abstract = "In the human leukemia K-562(S6) cell line (a) the accumulation of a-globin chains is low or absent, (b) ζ-globin gene expression is correlated with expression of ε-chains and (c) the genes responsible for the terminal cell division are not operated within 8-12 cell cycles, while K-562 (S6) cells are fully induced to erythroid differentiation.",

author = "R. Gambari and G. Raschell{\`a} and R. Biagini and M. Tripodi and Farace, {M. G.} and A. Romeo and A. Fantoni",

year = "1983",

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AU - Gambari, R.

AU - Raschellà, G.

AU - Biagini, R.

AU - Tripodi, M.

AU - Farace, M. G.

AU - Romeo, A.

AU - Fantoni, A.

PY - 1983

Y1 - 1983

N2 - In the human leukemia K-562(S6) cell line (a) the accumulation of a-globin chains is low or absent, (b) ζ-globin gene expression is correlated with expression of ε-chains and (c) the genes responsible for the terminal cell division are not operated within 8-12 cell cycles, while K-562 (S6) cells are fully induced to erythroid differentiation.

AB - In the human leukemia K-562(S6) cell line (a) the accumulation of a-globin chains is low or absent, (b) ζ-globin gene expression is correlated with expression of ε-chains and (c) the genes responsible for the terminal cell division are not operated within 8-12 cell cycles, while K-562 (S6) cells are fully induced to erythroid differentiation.

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Predominant expression of σ and ε globin genes in human leukemia K-562(S6) variant cell line

Abstract

ASJC Scopus subject areas

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