Preeclampsia, preterm delivery and infant cerebral palsy

Arsenio Spinillo, Ezio Capuzzo, Anna Cavallini, Mauro Stronati, Antonella De Santolo, Elisa Fazzi

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the association between preeclampsia and cerebral palsy among preterm infants. Study design: A cohort study of 345 singleton preterm (24 to 33 weeks gestation) infants delivered at an institution where no mothers received magnesium sulphate. We investigated the relationship of preeclampsia to the development of infant cerebral palsy (spastic quadriplegia, hemiplegia or diplegia) at two years' corrected age. Potential confounders were controlled for by politomous logistic regression analysis. Results: The prevalence of cerebral palsy in surviving infants from normotensive and preeclamptic pregnancies was 13.4% (38/284) and 3.3% (2/61), respectively (P=0.026 by Fisher exact test). After control for potential confounders (gestational age, infant gender, birthweight standard deviation score, mode of delivery), the likelihood of infant cerebral palsy was reduced by preeclampsia (odds ratio 0.16, 95% confidence interval=0.04-0.74 for infants from preeclamptic versus normotensive pregnancies being palsied). Conclusion: Among preterm infants, the protective effect of preeclampsia against cerebral palsy is manifest in the absence of magnesium sulphate utilization.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume77
Issue number2
DOIs
Publication statusPublished - Apr 1 1998

Keywords

  • Cerebral palsy
  • Magnesium sulphate
  • Preeclampsia
  • Preterm delivery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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