Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin

Vittorio De Franciscis, Rita Rosati, G. Luca Colucci-D'Amato, Alessandra Eva, Giancarlo Vecchio

Research output: Contribution to journalArticle

Abstract

We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.

Original languageEnglish
Pages (from-to)4234-4237
Number of pages4
JournalCancer Research
Volume51
Issue number16
Publication statusPublished - Aug 15 1991

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

De Franciscis, V., Rosati, R., Colucci-D'Amato, G. L., Eva, A., & Vecchio, G. (1991). Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. Cancer Research, 51(16), 4234-4237.