TY - JOUR
T1 - Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin
AU - De Franciscis, Vittorio
AU - Rosati, Rita
AU - Colucci-D'Amato, G. Luca
AU - Eva, Alessandra
AU - Vecchio, Giancarlo
PY - 1991/8/15
Y1 - 1991/8/15
N2 - We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
AB - We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
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M3 - Article
C2 - 1868443
AN - SCOPUS:0026000012
VL - 51
SP - 4234
EP - 4237
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 16
ER -