Abstract
We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
| Original language | English |
|---|---|
| Pages (from-to) | 4234-4237 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 51 |
| Issue number | 16 |
| Publication status | Published - Aug 15 1991 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. / De Franciscis, Vittorio; Rosati, Rita; Colucci-D'Amato, G. Luca; Eva, Alessandra; Vecchio, Giancarlo.
In: Cancer Research, Vol. 51, No. 16, 15.08.1991, p. 4234-4237.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin
AU - De Franciscis, Vittorio
AU - Rosati, Rita
AU - Colucci-D'Amato, G. Luca
AU - Eva, Alessandra
AU - Vecchio, Giancarlo
PY - 1991/8/15
Y1 - 1991/8/15
N2 - We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
AB - We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026000012&partnerID=8YFLogxK
M3 - Article
VL - 51
SP - 4234
EP - 4237
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 16
ER -