Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin

Vittorio De Franciscis, Rita Rosati, G. Luca Colucci-D'Amato, Alessandra Eva, Giancarlo Vecchio

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Abstract

We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These data, in agreement with our previous reports, suggest that the dbl protooncogene is expressed in a highly tissue-specific manner and indicate that this gene may be involved in the growth and differentiation of some cells of neuroectodermal origin.

Original languageEnglish
Pages (from-to)4234-4237
Number of pages4
JournalCancer Research
Volume51
Issue number16
Publication statusPublished - Aug 15 1991

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Neuroectodermal Tumors
Cell Differentiation
Neoplasms
Messenger RNA
Growth
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

De Franciscis, V., Rosati, R., Colucci-D'Amato, G. L., Eva, A., & Vecchio, G. (1991). Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. Cancer Research, 51(16), 4234-4237.

Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. / De Franciscis, Vittorio; Rosati, Rita; Colucci-D'Amato, G. Luca; Eva, Alessandra; Vecchio, Giancarlo.

In: Cancer Research, Vol. 51, No. 16, 15.08.1991, p. 4234-4237.

Research output: Contribution to journalArticle

De Franciscis, V, Rosati, R, Colucci-D'Amato, GL, Eva, A & Vecchio, G 1991, 'Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin', Cancer Research, vol. 51, no. 16, pp. 4234-4237.
De Franciscis V, Rosati R, Colucci-D'Amato GL, Eva A, Vecchio G. Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. Cancer Research. 1991 Aug 15;51(16):4234-4237.
De Franciscis, Vittorio ; Rosati, Rita ; Colucci-D'Amato, G. Luca ; Eva, Alessandra ; Vecchio, Giancarlo. / Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin. In: Cancer Research. 1991 ; Vol. 51, No. 16. pp. 4234-4237.
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