Preferential expression of Vβ6.7 domain on human peripheral CD4+ T cells. Implication for positive selection of T cells in man

Andrea Cossarizza, Meivyn Kahan, Claudio Ortolani, Claudio Franceschi, Marco Londei

Research output: Contribution to journalArticlepeer-review

Abstract

The peripheral T cell receptor repertoire is mainly controlled by the processes of positive and negative selection occurring in the thymus. Studies in normal or transgenic mice have provided compelling evidence for both negative and positive selection. Negative selection is characterized by partial or total disappearance from the periphery of T cells expressing certain Cβ regions, which are normally present in the thymus. Positive selection is chiefly characterized, in the periphery, by an imbalanced ratio between CD4+ and CD8+ T cells expressing a given V domain. To date little information concerning positive and negative selection has been available in man. We studied the distribution of 4 Vβ domains on CD4+ and CD8+ peripheral Tcells of 34 healthy individuals with a wide age-range (0-96 years). One of the Vβ domain studied, Vβ6.7, is preferentially expressed on CD4+ compared to CD8+ T cells (p > 0.001). No significant differences were observed using the other Vβ domain-specific monoclonal antibodies (Vβ5.2-5.3, 8 or 12). These results provide evidence that a process of thymic education, similar to that described in murine animal models, may also take place in man.

Original languageEnglish
Pages (from-to)1571-1574
Number of pages4
JournalEuropean Journal of Immunology
Volume21
Issue number6
Publication statusPublished - Jun 1991

ASJC Scopus subject areas

  • Immunology

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