Prefontal cortex in long-term memory: An "interference" approach using magnetic stimulation

Simone Rossi, Stefano F. Cappa, Claudio Babiloni, Patrizio Pasqualetti, Carlo Miniussi, Filippo Carducci, Fabio Babiloni, Paolo M. Rossini

Research output: Contribution to journalArticlepeer-review


Neuroimaging has consistently shown engagement of the prefrontal cortex during episodic memory tasks, but the functional relevance of this metabolic/hemodynamic activation in memory processing is still to be determined. We used repetitive transcranial magnetic stimulation (rTMS) to transiently interfere with either left or right prefrontal brain activity during the encoding or retrieval of pictures showing complex scenes. We found that the right dorsolateral prefrontal cortex (DLPFC) was crucial for the retrieval of the encoded pictorial information, whereas the left DLPFC was involved in encoding operations. This 'interference' approach allowed us to establish whether a cortical area activated by a memory task actually contributes to behavioral performance.

Original languageEnglish
Pages (from-to)948-952
Number of pages5
JournalNature Neuroscience
Issue number9
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Neuroscience(all)


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