Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance

Alessandro Bertolino, Grazia Caforio, Vittoria Petruzzella, Valeria Latorre, Valeria Rubino, Savino Dimalta, Alessandra Torraco, Giuseppe Blasi, Roberto Quartesan, Venkata S. Mattay, Joseph H. Callicott, Daniel R. Weinberger, Tommaso Scarabino

Research output: Contribution to journalArticlepeer-review

Abstract

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalPsychiatry Research - Neuroimaging
Volume147
Issue number2-3
DOIs
Publication statusPublished - Oct 30 2006

Keywords

  • Catechol-O-methyltransferase
  • Functional magnetic resonance imaging
  • Prefrontal cortex
  • Working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

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