Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy

A polysomnographic study

A. Romigi, F. Izzi, M. G. Marciani, F. Torelli, S. Zannino, L. R. Pisani, E. Uasone, F. Corte, F. Placidi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background and purpose: To evaluate the effects of pregabalin (PGB) adjunctive therapy on sleepwake cycle and daytime somnolence in adult patients affected by partial epilepsy. Methods: Twelve patients affected by partial epilepsy underwent a 24-h ambulatory polysomnography and a subjective evaluation of daytime somnolence by means of the Epworth Sleepiness Scale (ESS), before and after 3 months treatment with PGB. Results: Pregabalin therapy reduced seizures by >50% in 8 out of 12 patients. It induced a significant increase of REM sleep and a decrease of stage 2 NREM sleep (S2). A significant increase of the ESS score was observed without reaching the pathological cut-off value (mean ESS score

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalEuropean Journal of Neurology
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Partial Epilepsy
REM Sleep
Polysomnography
Sleep
Seizures
Therapeutics
Pregabalin

Keywords

  • Daytime somnolence
  • Epilepsy
  • Polysomnography
  • Pregabalin
  • REM sleep
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy : A polysomnographic study. / Romigi, A.; Izzi, F.; Marciani, M. G.; Torelli, F.; Zannino, S.; Pisani, L. R.; Uasone, E.; Corte, F.; Placidi, F.

In: European Journal of Neurology, Vol. 16, No. 1, 01.2009, p. 70-75.

Research output: Contribution to journalArticle

Romigi, A, Izzi, F, Marciani, MG, Torelli, F, Zannino, S, Pisani, LR, Uasone, E, Corte, F & Placidi, F 2009, 'Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: A polysomnographic study', European Journal of Neurology, vol. 16, no. 1, pp. 70-75. https://doi.org/10.1111/j.1468-1331.2008.02347.x
Romigi, A. ; Izzi, F. ; Marciani, M. G. ; Torelli, F. ; Zannino, S. ; Pisani, L. R. ; Uasone, E. ; Corte, F. ; Placidi, F. / Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy : A polysomnographic study. In: European Journal of Neurology. 2009 ; Vol. 16, No. 1. pp. 70-75.
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