Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: A polysomnographic study

A. Romigi, F. Izzi, M. G. Marciani, F. Torelli, S. Zannino, L. R. Pisani, E. Uasone, F. Corte, F. Placidi

Research output: Contribution to journalArticle

Abstract

Background and purpose: To evaluate the effects of pregabalin (PGB) adjunctive therapy on sleepwake cycle and daytime somnolence in adult patients affected by partial epilepsy. Methods: Twelve patients affected by partial epilepsy underwent a 24-h ambulatory polysomnography and a subjective evaluation of daytime somnolence by means of the Epworth Sleepiness Scale (ESS), before and after 3 months treatment with PGB. Results: Pregabalin therapy reduced seizures by >50% in 8 out of 12 patients. It induced a significant increase of REM sleep and a decrease of stage 2 NREM sleep (S2). A significant increase of the ESS score was observed without reaching the pathological cut-off value (mean ESS score

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalEuropean Journal of Neurology
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Daytime somnolence
  • Epilepsy
  • Polysomnography
  • Pregabalin
  • REM sleep
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Romigi, A., Izzi, F., Marciani, M. G., Torelli, F., Zannino, S., Pisani, L. R., Uasone, E., Corte, F., & Placidi, F. (2009). Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: A polysomnographic study. European Journal of Neurology, 16(1), 70-75. https://doi.org/10.1111/j.1468-1331.2008.02347.x