Pregnancy after renal transplantation in Italian patients: Focus on fetal outcome

Roberto Miniero, Irene Tardivo, Emilio Sergio Curtoni, Giuseppe Paolo Segoloni, Ennio La Rocca, Antonio Nino, Paola Todeschini, Carla Tregnaghi, Alberto Rosati, Paola Zanelli, Anna Maria Dall'Omo

Research output: Contribution to journalArticle

Abstract

Background. In the last few years advances in surgical techniques and immunosuppression have improved not only survival, but also quality of life in organ transplanted patients. Hence, the number of women of child-bearing age who decide to have a child - which means resuming a normal life - has increased. This multicenter retrospective study describes pregnancies after kidney transplantation and is the first such survey in Italy. Methods. We analyzed the outcomes from 56 pregnancies in 42 kidney transplant recipients from data collected in questionnaires, hospital records, and phone interviews. All recipients were maintained on cyclosporine (CsA), azathioprine (AZA), corticosteroids or tacrolimus (FK506) before and during pregnancy. Results. The average time from transplantation to childbirth was 62 months (range 12 to 180). Complications arose during pregnancy in 16 out of 36 term pregnancies (44.4%). Four transplant rejections (11.8%) were documented, two of them irreversible. Thirty-six infants were born, and 20 abortions reported (35.7%). Of these 36 babies, 16 (44.4%) were born at term, and 20 (55.6%) before term. Thirty-three Cesarean sections were performed (91.7%). Among the 20 pre-term babies, 11 can be grouped as follows: 5 low-birth-weight (LBW) (13.9%), 4 very low-birth-weight (VLBW) (8.3%) and 2 extremely very low-birth-weight (EVLBW) (5.6%). The children were followed up for periods ranging from 2 months to 13 years. Conclusions. In kidney transplant recipients who became pregnant the incidence of spontaneous abortion and preterm delivery was increased. Newborns delivered to these patients had low birth weight, but no congenital defects were noted and their development was normal.

Original languageEnglish
Pages (from-to)626-632
Number of pages7
JournalJournal of Nephrology
Volume15
Issue number6
Publication statusPublished - Nov 2002

Fingerprint

Kidney Transplantation
Pregnancy
Very Low Birth Weight Infant
Low Birth Weight Infant
Tacrolimus
Kidney
Hospital Records
Azathioprine
Graft Rejection
Spontaneous Abortion
Pregnancy Outcome
Cesarean Section
Immunosuppression
Italy
Cyclosporine
Multicenter Studies
Adrenal Cortex Hormones
Retrospective Studies
Transplantation
Quality of Life

Keywords

  • Kidney transplant
  • Newborn
  • Pregnancy

ASJC Scopus subject areas

  • Nephrology

Cite this

Miniero, R., Tardivo, I., Curtoni, E. S., Segoloni, G. P., La Rocca, E., Nino, A., ... Dall'Omo, A. M. (2002). Pregnancy after renal transplantation in Italian patients: Focus on fetal outcome. Journal of Nephrology, 15(6), 626-632.

Pregnancy after renal transplantation in Italian patients : Focus on fetal outcome. / Miniero, Roberto; Tardivo, Irene; Curtoni, Emilio Sergio; Segoloni, Giuseppe Paolo; La Rocca, Ennio; Nino, Antonio; Todeschini, Paola; Tregnaghi, Carla; Rosati, Alberto; Zanelli, Paola; Dall'Omo, Anna Maria.

In: Journal of Nephrology, Vol. 15, No. 6, 11.2002, p. 626-632.

Research output: Contribution to journalArticle

Miniero, R, Tardivo, I, Curtoni, ES, Segoloni, GP, La Rocca, E, Nino, A, Todeschini, P, Tregnaghi, C, Rosati, A, Zanelli, P & Dall'Omo, AM 2002, 'Pregnancy after renal transplantation in Italian patients: Focus on fetal outcome', Journal of Nephrology, vol. 15, no. 6, pp. 626-632.
Miniero R, Tardivo I, Curtoni ES, Segoloni GP, La Rocca E, Nino A et al. Pregnancy after renal transplantation in Italian patients: Focus on fetal outcome. Journal of Nephrology. 2002 Nov;15(6):626-632.
Miniero, Roberto ; Tardivo, Irene ; Curtoni, Emilio Sergio ; Segoloni, Giuseppe Paolo ; La Rocca, Ennio ; Nino, Antonio ; Todeschini, Paola ; Tregnaghi, Carla ; Rosati, Alberto ; Zanelli, Paola ; Dall'Omo, Anna Maria. / Pregnancy after renal transplantation in Italian patients : Focus on fetal outcome. In: Journal of Nephrology. 2002 ; Vol. 15, No. 6. pp. 626-632.
@article{5ad1fce728a84ebd9c017d64ba395cf9,
title = "Pregnancy after renal transplantation in Italian patients: Focus on fetal outcome",
abstract = "Background. In the last few years advances in surgical techniques and immunosuppression have improved not only survival, but also quality of life in organ transplanted patients. Hence, the number of women of child-bearing age who decide to have a child - which means resuming a normal life - has increased. This multicenter retrospective study describes pregnancies after kidney transplantation and is the first such survey in Italy. Methods. We analyzed the outcomes from 56 pregnancies in 42 kidney transplant recipients from data collected in questionnaires, hospital records, and phone interviews. All recipients were maintained on cyclosporine (CsA), azathioprine (AZA), corticosteroids or tacrolimus (FK506) before and during pregnancy. Results. The average time from transplantation to childbirth was 62 months (range 12 to 180). Complications arose during pregnancy in 16 out of 36 term pregnancies (44.4{\%}). Four transplant rejections (11.8{\%}) were documented, two of them irreversible. Thirty-six infants were born, and 20 abortions reported (35.7{\%}). Of these 36 babies, 16 (44.4{\%}) were born at term, and 20 (55.6{\%}) before term. Thirty-three Cesarean sections were performed (91.7{\%}). Among the 20 pre-term babies, 11 can be grouped as follows: 5 low-birth-weight (LBW) (13.9{\%}), 4 very low-birth-weight (VLBW) (8.3{\%}) and 2 extremely very low-birth-weight (EVLBW) (5.6{\%}). The children were followed up for periods ranging from 2 months to 13 years. Conclusions. In kidney transplant recipients who became pregnant the incidence of spontaneous abortion and preterm delivery was increased. Newborns delivered to these patients had low birth weight, but no congenital defects were noted and their development was normal.",
keywords = "Kidney transplant, Newborn, Pregnancy",
author = "Roberto Miniero and Irene Tardivo and Curtoni, {Emilio Sergio} and Segoloni, {Giuseppe Paolo} and {La Rocca}, Ennio and Antonio Nino and Paola Todeschini and Carla Tregnaghi and Alberto Rosati and Paola Zanelli and Dall'Omo, {Anna Maria}",
year = "2002",
month = "11",
language = "English",
volume = "15",
pages = "626--632",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Springer International Publishing",
number = "6",

}

TY - JOUR

T1 - Pregnancy after renal transplantation in Italian patients

T2 - Focus on fetal outcome

AU - Miniero, Roberto

AU - Tardivo, Irene

AU - Curtoni, Emilio Sergio

AU - Segoloni, Giuseppe Paolo

AU - La Rocca, Ennio

AU - Nino, Antonio

AU - Todeschini, Paola

AU - Tregnaghi, Carla

AU - Rosati, Alberto

AU - Zanelli, Paola

AU - Dall'Omo, Anna Maria

PY - 2002/11

Y1 - 2002/11

N2 - Background. In the last few years advances in surgical techniques and immunosuppression have improved not only survival, but also quality of life in organ transplanted patients. Hence, the number of women of child-bearing age who decide to have a child - which means resuming a normal life - has increased. This multicenter retrospective study describes pregnancies after kidney transplantation and is the first such survey in Italy. Methods. We analyzed the outcomes from 56 pregnancies in 42 kidney transplant recipients from data collected in questionnaires, hospital records, and phone interviews. All recipients were maintained on cyclosporine (CsA), azathioprine (AZA), corticosteroids or tacrolimus (FK506) before and during pregnancy. Results. The average time from transplantation to childbirth was 62 months (range 12 to 180). Complications arose during pregnancy in 16 out of 36 term pregnancies (44.4%). Four transplant rejections (11.8%) were documented, two of them irreversible. Thirty-six infants were born, and 20 abortions reported (35.7%). Of these 36 babies, 16 (44.4%) were born at term, and 20 (55.6%) before term. Thirty-three Cesarean sections were performed (91.7%). Among the 20 pre-term babies, 11 can be grouped as follows: 5 low-birth-weight (LBW) (13.9%), 4 very low-birth-weight (VLBW) (8.3%) and 2 extremely very low-birth-weight (EVLBW) (5.6%). The children were followed up for periods ranging from 2 months to 13 years. Conclusions. In kidney transplant recipients who became pregnant the incidence of spontaneous abortion and preterm delivery was increased. Newborns delivered to these patients had low birth weight, but no congenital defects were noted and their development was normal.

AB - Background. In the last few years advances in surgical techniques and immunosuppression have improved not only survival, but also quality of life in organ transplanted patients. Hence, the number of women of child-bearing age who decide to have a child - which means resuming a normal life - has increased. This multicenter retrospective study describes pregnancies after kidney transplantation and is the first such survey in Italy. Methods. We analyzed the outcomes from 56 pregnancies in 42 kidney transplant recipients from data collected in questionnaires, hospital records, and phone interviews. All recipients were maintained on cyclosporine (CsA), azathioprine (AZA), corticosteroids or tacrolimus (FK506) before and during pregnancy. Results. The average time from transplantation to childbirth was 62 months (range 12 to 180). Complications arose during pregnancy in 16 out of 36 term pregnancies (44.4%). Four transplant rejections (11.8%) were documented, two of them irreversible. Thirty-six infants were born, and 20 abortions reported (35.7%). Of these 36 babies, 16 (44.4%) were born at term, and 20 (55.6%) before term. Thirty-three Cesarean sections were performed (91.7%). Among the 20 pre-term babies, 11 can be grouped as follows: 5 low-birth-weight (LBW) (13.9%), 4 very low-birth-weight (VLBW) (8.3%) and 2 extremely very low-birth-weight (EVLBW) (5.6%). The children were followed up for periods ranging from 2 months to 13 years. Conclusions. In kidney transplant recipients who became pregnant the incidence of spontaneous abortion and preterm delivery was increased. Newborns delivered to these patients had low birth weight, but no congenital defects were noted and their development was normal.

KW - Kidney transplant

KW - Newborn

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=0036868248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036868248&partnerID=8YFLogxK

M3 - Article

C2 - 12495275

AN - SCOPUS:0036868248

VL - 15

SP - 626

EP - 632

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 6

ER -