Pregnancy and Cancer: the INCIP Project

for the International Network on Cancer, Infertility and Pregnancy (INCIP), Charlotte Maggen, Vera E.R.A. Wolters, Elyce Cardonick, Monica Fumagalli, Michael J. Halaska, Christianne A.R. Lok, Jorine de Haan, Katrien Van Tornout, Kristel Van Calsteren, Frédéric Amant

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Cancer diagnosis in young pregnant women challenges oncological decision-making. The International Network on Cancer, Infertility and Pregnancy (INCIP) aims to build on clinical recommendations based on worldwide collaborative research. Recent Findings: A pregnancy may complicate diagnostic and therapeutic oncological options, as the unborn child must be protected from potentially hazardous exposures. Pregnant patients should as much as possible be treated as non-pregnant patients, in order to preserve maternal prognosis. Some approaches need adaptations when compared with standard treatment for fetal reasons. Depending on the gestational age, surgery, radiotherapy, and chemotherapy are possible during pregnancy. A multidisciplinary approach is the best guarantee for experience-driven decisions. A setting with a high-risk obstetrical unit is strongly advised to safeguard fetal growth and health. Research wise, the INCIP invests in clinical follow-up of children, as cardiac function, neurodevelopment, cancer occurrence, and fertility theoretically may be affected. Furthermore, parental psychological coping strategies, (epi)genetic alterations, and pathophysiological placental changes secondary to cancer (treatment) are topics of ongoing research. Summary: Further international research is needed to provide patients diagnosed with cancer during pregnancy with the best individualized management plan to optimize obstetrical and oncological care.

Original languageEnglish
Article number17
JournalCurrent Oncology Reports
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 1 2020

Keywords

  • Cancer
  • Fertility
  • INCIP
  • Pregnancy
  • Research

ASJC Scopus subject areas

  • Oncology

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    for the International Network on Cancer, Infertility and Pregnancy (INCIP), Maggen, C., Wolters, V. E. R. A., Cardonick, E., Fumagalli, M., Halaska, M. J., Lok, C. A. R., de Haan, J., Van Tornout, K., Van Calsteren, K., & Amant, F. (2020). Pregnancy and Cancer: the INCIP Project. Current Oncology Reports, 22(2), [17]. https://doi.org/10.1007/s11912-020-0862-7