Pregnancy and melanoma: a European-wide survey to assess current management and a critical literature overview

S. Ribero, C Longo, Emi Dika, C Fortes, S Pasquali, E. Nagore, D. C. Glass, Caroline Robert, A. M M Eggermont, A Testori, P. Quaglino, P. Nathan, G Argenziano, S. Puig, V. Bataille, Members of the Melanoma Group of the EORTC

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Management of melanoma during pregnancy can be extremely challenging. The reported incidence of melanoma in pregnancy ranges from 2.8 to 5.0 per 100 000 pregnancies. There are no guidelines for the management of melanoma during pregnancy.

METHODS: The survey was designed to investigate the opinions of melanoma physicians on decision making in relation to pregnancy and melanoma. A clinical scenario-based survey on management of pregnancy in melanoma was distributed all over Europe via the membership of the EORTC and other European melanoma societies.

RESULTS: A total of 290 questionnaires were returned with a larger participation from southern Europe. A large heterogeneity was found for the answers given in the different clinical scenarios with 50% of the answers showing discordance, especially regarding sentinel lymph node biopsy during pregnancy. Discordant answers were also found for the counselling of women about a potential delay in getting pregnant after a high-risk melanoma (35% for a 2 year wait minimum vs. 57% no waiting needed), while for thin melanomas, as expected, there was more concordance with 70% of the physicians recommending no delay. Fifteen per cent of physicians recommended an abortion in stage II melanoma during the third month of pregnancy. Twenty per cent of the responders advised against hormonal replacement therapy in melanoma patients.

CONCLUSIONS: The management of melanoma during pregnancy varies widely in Europe. At present, there is a lack of consensus in Europe, which may lead to very important decisions in women with melanoma, and guidelines are needed.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Volume31
Issue number1
Early online dateMay 27 2016
DOIs
Publication statusPublished - Jan 2017

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Keywords

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Cite this

Ribero, S., Longo, C., Dika, E., Fortes, C., Pasquali, S., Nagore, E., Glass, D. C., Robert, C., Eggermont, A. M. M., Testori, A., Quaglino, P., Nathan, P., Argenziano, G., Puig, S., Bataille, V., & Members of the Melanoma Group of the EORTC (2017). Pregnancy and melanoma: a European-wide survey to assess current management and a critical literature overview. Journal of the European Academy of Dermatology and Venereology, 31(1), 65-69. https://doi.org/10.1111/jdv.13722