TY - JOUR
T1 - Pregnancy complications predict thrombotic events in young women with essential thrombocythemia
AU - Randi, Maria Luigia
AU - Bertozzi, Irene
AU - Rumi, Elisa
AU - Elena, Chiara
AU - Finazzi, Guido
AU - Vianelli, Nicola
AU - Polverelli, Nicola
AU - Ruggeri, Marco
AU - Vannucchi, Alessandro Maria
AU - Antonioli, Elisabetta
AU - Lussana, Federico
AU - Tieghi, Alessia
AU - Iurlo, Alessandra
AU - Elli, Elena
AU - Ruella, Marco
AU - Fabris, Fabrizio
AU - Cazzola, Mario
AU - Barbui, Tiziano
PY - 2014/3
Y1 - 2014/3
N2 - Although Philadelphia-negative myeloproliferative neoplasms (MPNs) occur typically in middle to advanced age, any age group may be affected, posing a challenge for their management during pregnancy when they occur in young females. There is a high incidence of thromboembolic events and pregnancy complications in patients with myeloproliferative neoplasms, and a possible relationship between these complications is a matter of concern. The aim of this article was to correlate thrombosis and pregnancy outcome in 158 females with ET experiencing 237 pregnancies. Seven patients had a thrombotic event before their first pregnancy, one of them ended (14.3%) in a miscarriage. Among the 151 patients with no history of thrombosis before they became pregnant, 40 (26.5%) had a miscarriage (P=NS). Eighteen patients (11.4%) developed major thrombotic complications (12 splanchnic vein, 1 cerebral vein, 2 coronary syndromes, and 3 strokes) after at least one pregnancy (4 uneventful and 14 complicated). The occurrence of thrombosis was significantly more frequent (P
AB - Although Philadelphia-negative myeloproliferative neoplasms (MPNs) occur typically in middle to advanced age, any age group may be affected, posing a challenge for their management during pregnancy when they occur in young females. There is a high incidence of thromboembolic events and pregnancy complications in patients with myeloproliferative neoplasms, and a possible relationship between these complications is a matter of concern. The aim of this article was to correlate thrombosis and pregnancy outcome in 158 females with ET experiencing 237 pregnancies. Seven patients had a thrombotic event before their first pregnancy, one of them ended (14.3%) in a miscarriage. Among the 151 patients with no history of thrombosis before they became pregnant, 40 (26.5%) had a miscarriage (P=NS). Eighteen patients (11.4%) developed major thrombotic complications (12 splanchnic vein, 1 cerebral vein, 2 coronary syndromes, and 3 strokes) after at least one pregnancy (4 uneventful and 14 complicated). The occurrence of thrombosis was significantly more frequent (P
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U2 - 10.1002/ajh.23635
DO - 10.1002/ajh.23635
M3 - Article
C2 - 24265194
AN - SCOPUS:84896698590
VL - 89
SP - 306
EP - 309
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -