Pregnancy complications predict thrombotic events in young women with essential thrombocythemia

Maria Luigia Randi, Irene Bertozzi, Elisa Rumi, Chiara Elena, Guido Finazzi, Nicola Vianelli, Nicola Polverelli, Marco Ruggeri, Alessandro Maria Vannucchi, Elisabetta Antonioli, Federico Lussana, Alessia Tieghi, Alessandra Iurlo, Elena Elli, Marco Ruella, Fabrizio Fabris, Mario Cazzola, Tiziano Barbui

Research output: Contribution to journalArticlepeer-review

Abstract

Although Philadelphia-negative myeloproliferative neoplasms (MPNs) occur typically in middle to advanced age, any age group may be affected, posing a challenge for their management during pregnancy when they occur in young females. There is a high incidence of thromboembolic events and pregnancy complications in patients with myeloproliferative neoplasms, and a possible relationship between these complications is a matter of concern. The aim of this article was to correlate thrombosis and pregnancy outcome in 158 females with ET experiencing 237 pregnancies. Seven patients had a thrombotic event before their first pregnancy, one of them ended (14.3%) in a miscarriage. Among the 151 patients with no history of thrombosis before they became pregnant, 40 (26.5%) had a miscarriage (P=NS). Eighteen patients (11.4%) developed major thrombotic complications (12 splanchnic vein, 1 cerebral vein, 2 coronary syndromes, and 3 strokes) after at least one pregnancy (4 uneventful and 14 complicated). The occurrence of thrombosis was significantly more frequent (P

Original languageEnglish
Pages (from-to)306-309
Number of pages4
JournalAmerican Journal of Hematology
Volume89
Issue number3
DOIs
Publication statusPublished - Mar 2014

ASJC Scopus subject areas

  • Hematology

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