Pregnancy in women with chronic renal failure1

Enrico Imbasciata, Giorgio Pardi, Piero Capetta, Giancarlo Ambroso, Patrizia Bozzetti, Bruno Pagliari, Claudio Ponticelli

Research output: Contribution to journalArticlepeer-review


We describe 19 pregnancies in 18 women with chronic renal disease and plasma creatinine ≥ 1.6 mg/dl before pregnancy. There were 2 spontaneous abortions (11th and 21st week), 2 therapeutic abortions (18th and 19th week), 1 stillbirth (30th week), 1 neonatal death (31st week) and 13 live births, 7 of them were preterm. Nine cesarean sections were done. Serial determinations of plasma creatinine during pregnancy showed a trend to decrease during the first half and to increase during the second half of pregnancy. The effect of pregnancy on the progression of renal failure was evaluated in 14 patients by comparing the linear regression lines of reciprocal plasma creatinine versus time before and after pregnancy. In 5 patients the rate of progression worsened after pregnancy. Our data indicate that women with chronic renal failure may have a successful pregnancy, but one third of them will have an accelerated rate of progression of the disease.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalAmerican Journal of Nephrology
Issue number3
Publication statusPublished - 1986


  • Chronic renal failure
  • Pregnancy
  • Progression of renal diseases

ASJC Scopus subject areas

  • Nephrology


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