Pregnancy in women with pre-existing lupus nephritis: Predictors of fetal and maternal outcome

Enrico Imbasciati, Angela Tincani, Gina Gregorini, Andrea Doria, Gabriella Moroni, Gianfranca Cabiddu, Daniele Marcelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Only few data are available on pregnancy in patients with lupus nephritis (LN) diagnosed before conception. The aim of this study was to identify the risk factors for complicated pregnancy in women with pre-existing LN. Methods. In a multicentre study, we collected data on 113 pregnancies occurring in 81 women with pre-existing biopsy-proven LN. Primary outcomes were fetal loss including perinatal death and renal flares during and 12 months after pregnancy. Univariate and logistic regression analyses were used to identify predictors of outcomes. Results. Renal biopsy performed 7.2 ± 4.9 years before pregnancy showed the following WHO classes: 6 patients in II, 8 in III, 48 in IV and 19 in V. At conception, most patients were in complete (49%) or partial (27%) remission. There were nine spontaneous abortions, one stillbirth and five neonatal deaths. Thirty-one deliveries were preterm. Birth weight was

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalNephrology Dialysis Transplantation
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Fetal outcome
  • Lupus nephritis
  • Pregnancy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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