Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes

N. Cester, R. Staffolani, R. A. Rabini, R. Magnanelli, E. Salvolini, R. Galassi, L. Mazzanti, C. Romanini

Research output: Contribution to journalArticle

Abstract

It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which are by themselves able to induce smooth muscle constriction and increased pressor responsiveness to angiotensin II. In order to investigate this issue, we studied the basal content of lipid peroxides in terms of malondialdehyde (MDA) in the syncytiotrophoblast plasma membranes (SPM) from PIH women. Moreover, we investigated the susceptibility to peroxidation of SPM using an in vitro oxidative stress as a tool to verify the predisposition to the in vivo development of peroxidation products. The fatty acid composition of the membranes was also analyzed. Microvillus membrane lipoperoxide concentrations were significantly increased in PIH women (62.8±7.6 ng MDA/mg prot) compared with healthy pregnant subjects (37.6±4.8 ng MDA/mg prot; p

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume131
Issue number2
DOIs
Publication statusPublished - Feb 1994

Fingerprint

Pregnancy Induced Hypertension
Lipid Peroxides
Cell membranes
Microvilli
Malondialdehyde
Endothelial cells
Cell Membrane
Trophoblasts
Endothelial Cells
Membranes
Oxidative stress
Oxidants
Constriction
Angiotensin II
Smooth Muscle
Muscle
Healthy Volunteers
Oxidative Stress
Fatty Acids
Antioxidants

Keywords

  • fatty acid content
  • lipid peroxidation
  • men
  • pregnancy induced hypertension
  • syncytiotrophoblast plasma membrane

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Cester, N., Staffolani, R., Rabini, R. A., Magnanelli, R., Salvolini, E., Galassi, R., ... Romanini, C. (1994). Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes. Molecular and Cellular Biochemistry, 131(2), 151-155. https://doi.org/10.1007/BF00925951

Pregnancy induced hypertension : a role for peroxidation in microvillus plasma membranes. / Cester, N.; Staffolani, R.; Rabini, R. A.; Magnanelli, R.; Salvolini, E.; Galassi, R.; Mazzanti, L.; Romanini, C.

In: Molecular and Cellular Biochemistry, Vol. 131, No. 2, 02.1994, p. 151-155.

Research output: Contribution to journalArticle

Cester, N, Staffolani, R, Rabini, RA, Magnanelli, R, Salvolini, E, Galassi, R, Mazzanti, L & Romanini, C 1994, 'Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes', Molecular and Cellular Biochemistry, vol. 131, no. 2, pp. 151-155. https://doi.org/10.1007/BF00925951
Cester, N. ; Staffolani, R. ; Rabini, R. A. ; Magnanelli, R. ; Salvolini, E. ; Galassi, R. ; Mazzanti, L. ; Romanini, C. / Pregnancy induced hypertension : a role for peroxidation in microvillus plasma membranes. In: Molecular and Cellular Biochemistry. 1994 ; Vol. 131, No. 2. pp. 151-155.
@article{25c6efc64a6c49b6aaa3c608332567ec,
title = "Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes",
abstract = "It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which are by themselves able to induce smooth muscle constriction and increased pressor responsiveness to angiotensin II. In order to investigate this issue, we studied the basal content of lipid peroxides in terms of malondialdehyde (MDA) in the syncytiotrophoblast plasma membranes (SPM) from PIH women. Moreover, we investigated the susceptibility to peroxidation of SPM using an in vitro oxidative stress as a tool to verify the predisposition to the in vivo development of peroxidation products. The fatty acid composition of the membranes was also analyzed. Microvillus membrane lipoperoxide concentrations were significantly increased in PIH women (62.8±7.6 ng MDA/mg prot) compared with healthy pregnant subjects (37.6±4.8 ng MDA/mg prot; p",
keywords = "fatty acid content, lipid peroxidation, men, pregnancy induced hypertension, syncytiotrophoblast plasma membrane",
author = "N. Cester and R. Staffolani and Rabini, {R. A.} and R. Magnanelli and E. Salvolini and R. Galassi and L. Mazzanti and C. Romanini",
year = "1994",
month = "2",
doi = "10.1007/BF00925951",
language = "English",
volume = "131",
pages = "151--155",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Pregnancy induced hypertension

T2 - a role for peroxidation in microvillus plasma membranes

AU - Cester, N.

AU - Staffolani, R.

AU - Rabini, R. A.

AU - Magnanelli, R.

AU - Salvolini, E.

AU - Galassi, R.

AU - Mazzanti, L.

AU - Romanini, C.

PY - 1994/2

Y1 - 1994/2

N2 - It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which are by themselves able to induce smooth muscle constriction and increased pressor responsiveness to angiotensin II. In order to investigate this issue, we studied the basal content of lipid peroxides in terms of malondialdehyde (MDA) in the syncytiotrophoblast plasma membranes (SPM) from PIH women. Moreover, we investigated the susceptibility to peroxidation of SPM using an in vitro oxidative stress as a tool to verify the predisposition to the in vivo development of peroxidation products. The fatty acid composition of the membranes was also analyzed. Microvillus membrane lipoperoxide concentrations were significantly increased in PIH women (62.8±7.6 ng MDA/mg prot) compared with healthy pregnant subjects (37.6±4.8 ng MDA/mg prot; p

AB - It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which are by themselves able to induce smooth muscle constriction and increased pressor responsiveness to angiotensin II. In order to investigate this issue, we studied the basal content of lipid peroxides in terms of malondialdehyde (MDA) in the syncytiotrophoblast plasma membranes (SPM) from PIH women. Moreover, we investigated the susceptibility to peroxidation of SPM using an in vitro oxidative stress as a tool to verify the predisposition to the in vivo development of peroxidation products. The fatty acid composition of the membranes was also analyzed. Microvillus membrane lipoperoxide concentrations were significantly increased in PIH women (62.8±7.6 ng MDA/mg prot) compared with healthy pregnant subjects (37.6±4.8 ng MDA/mg prot; p

KW - fatty acid content

KW - lipid peroxidation

KW - men

KW - pregnancy induced hypertension

KW - syncytiotrophoblast plasma membrane

UR - http://www.scopus.com/inward/record.url?scp=0028266181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028266181&partnerID=8YFLogxK

U2 - 10.1007/BF00925951

DO - 10.1007/BF00925951

M3 - Article

C2 - 8035780

AN - SCOPUS:0028266181

VL - 131

SP - 151

EP - 155

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 2

ER -