Pregnancy induced hypertension: a role for peroxidation in microvillus plasma membranes

N. Cester, R. Staffolani, R. A. Rabini, R. Magnanelli, E. Salvolini, R. Galassi, L. Mazzanti, C. Romanini

Research output: Contribution to journalArticlepeer-review

Abstract

It has been recently hypothesized that in PIH a placental oxidant-antioxidant imbalance might cause the release of lipoperoxidation products into the circulation, with subsequent damage of endothelial cell membranes. In this hypothesis the endothelial cell and further increase in circulating lipoperoxide levels, which are by themselves able to induce smooth muscle constriction and increased pressor responsiveness to angiotensin II. In order to investigate this issue, we studied the basal content of lipid peroxides in terms of malondialdehyde (MDA) in the syncytiotrophoblast plasma membranes (SPM) from PIH women. Moreover, we investigated the susceptibility to peroxidation of SPM using an in vitro oxidative stress as a tool to verify the predisposition to the in vivo development of peroxidation products. The fatty acid composition of the membranes was also analyzed. Microvillus membrane lipoperoxide concentrations were significantly increased in PIH women (62.8±7.6 ng MDA/mg prot) compared with healthy pregnant subjects (37.6±4.8 ng MDA/mg prot; p

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume131
Issue number2
DOIs
Publication statusPublished - Feb 1994

Keywords

  • fatty acid content
  • lipid peroxidation
  • men
  • pregnancy induced hypertension
  • syncytiotrophoblast plasma membrane

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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