Pregnancy induced hypertension: Observations on chemical-physical properties of syncytiotrophoblast plasma membranes from human placenta

N. Cester, L. Mazzanti, G. Benedetti, A. M. Cugini, R. A. Rabini, A. L. Tranquilli, H. Valensise, C. Romanini

Research output: Contribution to journalArticlepeer-review

Abstract

The Pregnancy Induced Hypertension (PIH) was associated to alterations of ion transport, which may be due to abnormalities of membrane composition and function.We studied the syncytiotrophoblast plasma membranes of PIH mothers compared with normal ones.We observed a decreased microviscosity and an alteration of cholesterol to phospholipid ratio, together with an increased percentage of unsaturated fatty acid respect to the controls. We therefore hypothesized an involvment of the chemical-physical properties of the syncytiotrophoblast plasma membranes in the modified functional properties observed in the PIH.

Original languageEnglish
Pages (from-to)57-66
Number of pages10
JournalHypertension in Pregnancy
VolumeB7
Issue number1-2
DOIs
Publication statusPublished - 1988

Keywords

  • Lipid composition
  • Microviscosity
  • Pregnancy Induced Hypertension
  • Syncytiotrophoblast plasma membranes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Internal Medicine

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