Pregnancy loss and assisted reproduction: Preliminary results after the law 40/2004 in Italy

Giovanni Battista La Sala, Andrea Gallinelli, Alessia Nicoli, Maria Teresa Villani, Giuseppe Nucera

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The new Italian law on assisted reproduction technology rules that no more than three oocytes can be fertilized at one time, and that all embryos obtained must be transferred to the maternal uterus simultaneously. The aim of the present study was to investigate the influence of the new law on spontaneous embryonic/fetal losses through comparison of data collected over an identical period of time: the first year of application of the new law compared with the same time period 1 year before (March 10, 2004 to March 9, 2005 versus March 10, 2003 to March 9, 2004). A total of 271 clinical pregnancies were analysed. In the post-law period, a significantly lower percentage of total spontaneous embryonic losses compared with the pre-law period, and a higher percentage of surviving embryos in singletons and twins was observed. In conclusion, the impact of the limitations imposed by the new legislation regulating assisted reproduction in Italy seems to exert positive effects on spontaneous embryonic loss both in singletons and multiple pregnancies. These findings are in contrast to international predictions on this issue and, in general, are counter-intuitive. This suggests that further investigations on a larger cohort of women are required to confirm these preliminary results.

Original languageEnglish
Article number2272
Pages (from-to)65-70
Number of pages6
JournalReproductive BioMedicine Online
Volume13
Issue number1
Publication statusPublished - Jul 2006

Fingerprint

Italy
Reproduction
Pregnancy
Embryonic Structures
Multiple Pregnancy
Legislation
Uterus
Oocytes
Mothers
Technology

Keywords

  • Assisted reproduction
  • ICSI
  • Italian law
  • IVF
  • Recurrent miscarriage
  • Spontaneous abortion

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

La Sala, G. B., Gallinelli, A., Nicoli, A., Villani, M. T., & Nucera, G. (2006). Pregnancy loss and assisted reproduction: Preliminary results after the law 40/2004 in Italy. Reproductive BioMedicine Online, 13(1), 65-70. [2272].

Pregnancy loss and assisted reproduction : Preliminary results after the law 40/2004 in Italy. / La Sala, Giovanni Battista; Gallinelli, Andrea; Nicoli, Alessia; Villani, Maria Teresa; Nucera, Giuseppe.

In: Reproductive BioMedicine Online, Vol. 13, No. 1, 2272, 07.2006, p. 65-70.

Research output: Contribution to journalArticle

La Sala, GB, Gallinelli, A, Nicoli, A, Villani, MT & Nucera, G 2006, 'Pregnancy loss and assisted reproduction: Preliminary results after the law 40/2004 in Italy', Reproductive BioMedicine Online, vol. 13, no. 1, 2272, pp. 65-70.
La Sala, Giovanni Battista ; Gallinelli, Andrea ; Nicoli, Alessia ; Villani, Maria Teresa ; Nucera, Giuseppe. / Pregnancy loss and assisted reproduction : Preliminary results after the law 40/2004 in Italy. In: Reproductive BioMedicine Online. 2006 ; Vol. 13, No. 1. pp. 65-70.
@article{6fe9cdcce1154075bab7e97748915f8e,
title = "Pregnancy loss and assisted reproduction: Preliminary results after the law 40/2004 in Italy",
abstract = "The new Italian law on assisted reproduction technology rules that no more than three oocytes can be fertilized at one time, and that all embryos obtained must be transferred to the maternal uterus simultaneously. The aim of the present study was to investigate the influence of the new law on spontaneous embryonic/fetal losses through comparison of data collected over an identical period of time: the first year of application of the new law compared with the same time period 1 year before (March 10, 2004 to March 9, 2005 versus March 10, 2003 to March 9, 2004). A total of 271 clinical pregnancies were analysed. In the post-law period, a significantly lower percentage of total spontaneous embryonic losses compared with the pre-law period, and a higher percentage of surviving embryos in singletons and twins was observed. In conclusion, the impact of the limitations imposed by the new legislation regulating assisted reproduction in Italy seems to exert positive effects on spontaneous embryonic loss both in singletons and multiple pregnancies. These findings are in contrast to international predictions on this issue and, in general, are counter-intuitive. This suggests that further investigations on a larger cohort of women are required to confirm these preliminary results.",
keywords = "Assisted reproduction, ICSI, Italian law, IVF, Recurrent miscarriage, Spontaneous abortion",
author = "{La Sala}, {Giovanni Battista} and Andrea Gallinelli and Alessia Nicoli and Villani, {Maria Teresa} and Giuseppe Nucera",
year = "2006",
month = "7",
language = "English",
volume = "13",
pages = "65--70",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier Ltd",
number = "1",

}

TY - JOUR

T1 - Pregnancy loss and assisted reproduction

T2 - Preliminary results after the law 40/2004 in Italy

AU - La Sala, Giovanni Battista

AU - Gallinelli, Andrea

AU - Nicoli, Alessia

AU - Villani, Maria Teresa

AU - Nucera, Giuseppe

PY - 2006/7

Y1 - 2006/7

N2 - The new Italian law on assisted reproduction technology rules that no more than three oocytes can be fertilized at one time, and that all embryos obtained must be transferred to the maternal uterus simultaneously. The aim of the present study was to investigate the influence of the new law on spontaneous embryonic/fetal losses through comparison of data collected over an identical period of time: the first year of application of the new law compared with the same time period 1 year before (March 10, 2004 to March 9, 2005 versus March 10, 2003 to March 9, 2004). A total of 271 clinical pregnancies were analysed. In the post-law period, a significantly lower percentage of total spontaneous embryonic losses compared with the pre-law period, and a higher percentage of surviving embryos in singletons and twins was observed. In conclusion, the impact of the limitations imposed by the new legislation regulating assisted reproduction in Italy seems to exert positive effects on spontaneous embryonic loss both in singletons and multiple pregnancies. These findings are in contrast to international predictions on this issue and, in general, are counter-intuitive. This suggests that further investigations on a larger cohort of women are required to confirm these preliminary results.

AB - The new Italian law on assisted reproduction technology rules that no more than three oocytes can be fertilized at one time, and that all embryos obtained must be transferred to the maternal uterus simultaneously. The aim of the present study was to investigate the influence of the new law on spontaneous embryonic/fetal losses through comparison of data collected over an identical period of time: the first year of application of the new law compared with the same time period 1 year before (March 10, 2004 to March 9, 2005 versus March 10, 2003 to March 9, 2004). A total of 271 clinical pregnancies were analysed. In the post-law period, a significantly lower percentage of total spontaneous embryonic losses compared with the pre-law period, and a higher percentage of surviving embryos in singletons and twins was observed. In conclusion, the impact of the limitations imposed by the new legislation regulating assisted reproduction in Italy seems to exert positive effects on spontaneous embryonic loss both in singletons and multiple pregnancies. These findings are in contrast to international predictions on this issue and, in general, are counter-intuitive. This suggests that further investigations on a larger cohort of women are required to confirm these preliminary results.

KW - Assisted reproduction

KW - ICSI

KW - Italian law

KW - IVF

KW - Recurrent miscarriage

KW - Spontaneous abortion

UR - http://www.scopus.com/inward/record.url?scp=33745961936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745961936&partnerID=8YFLogxK

M3 - Article

C2 - 16820111

AN - SCOPUS:33745961936

VL - 13

SP - 65

EP - 70

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 1

M1 - 2272

ER -