Pregnancy luteoma with granulosa cell proliferation: An unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia

S. Piana, F. F. Nogales, S. Corrado, L. Cardinale, D. Gusolfino, F. Rivasi

Research output: Contribution to journalArticle


A pregnancy luteoma (PL) was incidentally found at a term cesarean section in a 27-year-old black woman without any endocrine abnormality. The lesion involved only the left ovary; it had a nodular and focal pseudoalveolar growth pattern and was associated with areas of tubular sertoliform component, consistent with granulosa cell proliferation. Immunohistochemistry revealed a diffuse positivity to Inhibin A, CD99, cytokeratin and vimentin. The ultrastructure was typical of steroid-producing cells. PL is a tumor-like lesion arising in pregnant women and often misdiagnosed as a neoplastic lesion; awareness of this rare entity and its differential diagnoses may avoid unnecessary surgery in young patients.

Original languageEnglish
Pages (from-to)859-863
Number of pages5
JournalPathology Research and Practice
Issue number12
Publication statusPublished - 1999



  • Granulosa cell
  • Immunohistochemistry
  • Luteoma
  • Ovary
  • Pregnancy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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