Pregnancy outcomes after peripheral blood or bone marrow transplantation: A retrospective survey

N. Salooja, R. M. Szydlo, G. Socie, B. Rio, R. Chatterjee, P. Ljungman, M. T. Van Lint, R. Powles, G. Jackson, M. Hinterberger-Fischer, H. J. Kolb, J. F. Apperley

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Abstract

Background: Some patients treated by transplantation of haemopoietic stem cells (peripheral blood or bone marrow) become permanently infertile, but others retain or recover fertility. We assessed the outcome of conception in women, and partners of men previously treated by autologous or allogeneic stem cell transplantation (SCT). Methods: We sent questionnaires to 229 centres of the European Group for Blood and Marrow Transplantation. We sought details about the original disease, transplant procedure, and outcome of conception for both male and female patients. Findings: 199 centres gave information relating to 19 412 allogeneic and 17 950 autologous transplant patients. 232 (0.6%) patients conceived after SCT. Crude annual birth rate for 4-month survivors of SCT was lower than the national average for England and Wales at 1.7 per 1000 patients. 312 conceptions were reported in 113 patients (74 allograft) and partners of 119 patients (93 allograft). Most pregnancies were uncomplicated and resulted in 271 livebirths. 28 (42%) of 67 allograft recipients had caesarean section compared with 16% in the normal population (difference = 26% [95% CI 15-38]), 12 (20%) of 59 had preterm delivery compared with a normal rate of 6% (14% [4-24]), and 12 (23%) of 52 had low birthweight singleton offspring compared with a normal rate of 6% (17% [6-29]). Interpretation: Pregnancy after SCT is likely to have a successful outcome. Pregnancies in allograft patients who have received total body irradiation should be treated as high risk for maternal and fetal complications.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalLancet
Volume358
Issue number9278
DOIs
Publication statusPublished - Jul 28 2001

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Pregnancy Outcome
Bone Marrow Transplantation
Stem Cell Transplantation
Allografts
Pregnancy
Peripheral Blood Stem Cell Transplantation
Information Centers
Surveys and Questionnaires
Whole-Body Irradiation
Birth Rate
Wales
Autografts
Cesarean Section
England
Fertility
Survivors
Bone Marrow
Mothers
Transplants
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Salooja, N., Szydlo, R. M., Socie, G., Rio, B., Chatterjee, R., Ljungman, P., ... Apperley, J. F. (2001). Pregnancy outcomes after peripheral blood or bone marrow transplantation: A retrospective survey. Lancet, 358(9278), 271-276. https://doi.org/10.1016/S0140-6736(01)05482-4

Pregnancy outcomes after peripheral blood or bone marrow transplantation : A retrospective survey. / Salooja, N.; Szydlo, R. M.; Socie, G.; Rio, B.; Chatterjee, R.; Ljungman, P.; Van Lint, M. T.; Powles, R.; Jackson, G.; Hinterberger-Fischer, M.; Kolb, H. J.; Apperley, J. F.

In: Lancet, Vol. 358, No. 9278, 28.07.2001, p. 271-276.

Research output: Contribution to journalArticle

Salooja, N, Szydlo, RM, Socie, G, Rio, B, Chatterjee, R, Ljungman, P, Van Lint, MT, Powles, R, Jackson, G, Hinterberger-Fischer, M, Kolb, HJ & Apperley, JF 2001, 'Pregnancy outcomes after peripheral blood or bone marrow transplantation: A retrospective survey', Lancet, vol. 358, no. 9278, pp. 271-276. https://doi.org/10.1016/S0140-6736(01)05482-4
Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: A retrospective survey. Lancet. 2001 Jul 28;358(9278):271-276. https://doi.org/10.1016/S0140-6736(01)05482-4
Salooja, N. ; Szydlo, R. M. ; Socie, G. ; Rio, B. ; Chatterjee, R. ; Ljungman, P. ; Van Lint, M. T. ; Powles, R. ; Jackson, G. ; Hinterberger-Fischer, M. ; Kolb, H. J. ; Apperley, J. F. / Pregnancy outcomes after peripheral blood or bone marrow transplantation : A retrospective survey. In: Lancet. 2001 ; Vol. 358, No. 9278. pp. 271-276.
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abstract = "Background: Some patients treated by transplantation of haemopoietic stem cells (peripheral blood or bone marrow) become permanently infertile, but others retain or recover fertility. We assessed the outcome of conception in women, and partners of men previously treated by autologous or allogeneic stem cell transplantation (SCT). Methods: We sent questionnaires to 229 centres of the European Group for Blood and Marrow Transplantation. We sought details about the original disease, transplant procedure, and outcome of conception for both male and female patients. Findings: 199 centres gave information relating to 19 412 allogeneic and 17 950 autologous transplant patients. 232 (0.6{\%}) patients conceived after SCT. Crude annual birth rate for 4-month survivors of SCT was lower than the national average for England and Wales at 1.7 per 1000 patients. 312 conceptions were reported in 113 patients (74 allograft) and partners of 119 patients (93 allograft). Most pregnancies were uncomplicated and resulted in 271 livebirths. 28 (42{\%}) of 67 allograft recipients had caesarean section compared with 16{\%} in the normal population (difference = 26{\%} [95{\%} CI 15-38]), 12 (20{\%}) of 59 had preterm delivery compared with a normal rate of 6{\%} (14{\%} [4-24]), and 12 (23{\%}) of 52 had low birthweight singleton offspring compared with a normal rate of 6{\%} (17{\%} [6-29]). Interpretation: Pregnancy after SCT is likely to have a successful outcome. Pregnancies in allograft patients who have received total body irradiation should be treated as high risk for maternal and fetal complications.",
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AU - Szydlo, R. M.

AU - Socie, G.

AU - Rio, B.

AU - Chatterjee, R.

AU - Ljungman, P.

AU - Van Lint, M. T.

AU - Powles, R.

AU - Jackson, G.

AU - Hinterberger-Fischer, M.

AU - Kolb, H. J.

AU - Apperley, J. F.

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