Pregnancy outcomes among ART-naive and ART-experienced HIV-positive women: Data from the ICONA foundation study group, years 1997-2013

Antonella D'Arminio Monforte, Laura Galli, Sergio Lo Caputo, Miriam Lichtner, Carmela Pinnetti, Nicoletta Bobbio, Daniela Francisci, Andrea Costantini, Antonella Cingolani, Francesco Castelli, Enrico Girardi, Antonella Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We analyzed antiretroviral therapy (ART) regimens and pregnancy outcomes in naive and ART-experienced HIV-positive women from Italian Cohort Naive Antiretrovirals cohort and investigated frequency and predictors of detectable viral load (VL) at delivery. Methods: All pregnancies resulting in live births were included. Based on ART at the beginning of pregnancy, pregnancies were allocated either to the ART-naive or ART-experienced group. Analyses were stratified according to calendar periods. Multivariate logistic regression was used to describe predictors of detectable VL at delivery. Results: One hundred fifty-eight of 2862 women experienced 169 pregnancies (88 in naives and 81 in 70 ART-experienced women). ART regimens varied according to calendar periods; mono-dual combination regimens progressively decreased over time (P value for trend 50 copies per milliliter at pregnancy ascertainment (adjusted odds ratio: 7.1, 95% confidence interval: 1.9 to 33.3, P = 0.006). Nevertheless, no cases of vertical transmission were diagnosed. Preterm birth rate of 17.3% (11.9% vs 22.6% naive and ART experienced, P = 0.1) was reported; this was not associated with ART duration or protease inhibitor-including regimens; 27.2% of infants had

Original languageEnglish
Pages (from-to)258-267
Number of pages10
JournalJournal of Acquired Immune Deficiency Syndromes
Volume67
Issue number3
Publication statusPublished - 2014

Keywords

  • ART experienced
  • ART naives
  • Detectable viral load
  • Pregnancy
  • Preterm delivery

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Medicine(all)

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