Pregnancy registries in epilepsy

Ettore Beghi, John F. Annegers, Dina Battino, John Mumford, Merrel Dow, Georgia Montouris, Martha Morrell, James I. Morrow, Emilio Perucca, Sanjeev V. Thomas, Patricia Tennis, Torbjorn Tomson, Frank Vajda, Mark Yerby

Research output: Contribution to journalArticle

Abstract

The risk of major malformations in the offspring of mothers with epilepsy receiving antiepileptic drugs is 4-8% compared to 2-4% in the general population. Risk factors include daily dose and polytherapy. Selected drugs have been found to be associated with a higher risk of specific malformations (congenital heart defects and cleft palate with phenytoin and barbiturates; neural tube defects with valproate and carbamazepine). Although some of these findings are unquestionable, several questions are still unsolved, depending on the characteristics of the target populations, the small samples of patients, and the design and limiting factors of the published reports. In the last decade, pregnancy registries have been activated by collaborative groups of physicians in Europe (EURAP), North America (NAREP), Australia and India (the latter two recently merged into EURAP), to enroll a large number of exposed women to be monitored prospectively with standardized methods, and by three pharmaceutical companies marketing lamotrigine, gabapentin and vigabatrin, as part of their post-marketing surveillance. Even though the structure of these registries and the target populations should theoretically result in the identification of a sufficient number of women exposed to different drugs and examined for the occurrence of malformations of any type and severity, the implementation of a common database with information from the existing registries may provide valuable information in a shorter time period. Although differences between some of the registries limit the possibility to pool data, a gradual development of a collaboration is highly desirable to discuss a list of design issues and assess to what extent and how data could be compared and organized.

Original languageEnglish
Pages (from-to)1422-1425
Number of pages4
JournalEpilepsia
Volume42
Issue number11
DOIs
Publication statusPublished - 2001

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Keywords

  • Database
  • Epilepsy
  • Pregnancy
  • Registry
  • Teratogenesis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Beghi, E., Annegers, J. F., Battino, D., Mumford, J., Dow, M., Montouris, G., Morrell, M., Morrow, J. I., Perucca, E., Thomas, S. V., Tennis, P., Tomson, T., Vajda, F., & Yerby, M. (2001). Pregnancy registries in epilepsy. Epilepsia, 42(11), 1422-1425. https://doi.org/10.1046/j.1528-1157.2001.11201.x