Abstract
Young pregnant women with HIV may be at significant risk of unplanned pregnancy, lower treatment coverage, and other adverse pregnancy outcomes. In a large cohort of pregnant women with HIV in Italy, among 2979 pregnancies followed in 2001-2016, 9.0% were in women <25 years, with a significant increase over time (2001-2005: 7.0%; 2006-2010: 9.1%; 2011-2016: 12.2%, P < 0.001). Younger women had a lower rate of planned pregnancy (23.2% vs. 37.7%, odds ratio (OR) 0.50, 95% confidence interval (CI) 0.36-0.69), were more frequently diagnosed with HIV in pregnancy (46.5% vs. 20.9%, OR 3.29, 95% CI 2.54-4.25), and, if already diagnosed with HIV before pregnancy, were less frequently on antiretroviral treatment at conception (<25 years: 56.3%; ≥25 years: 69.0%, OR 0.58, 95% CI 0.41-0.81). During pregnancy, treatment coverage was almost universal in both age groups (98.5% vs. 99.3%), with no differences in rate of HIV viral suppression at third trimester and adverse pregnancy outcomes. The data show that young women represent a growing proportion of pregnant women with HIV, and are significantly more likely to have unplanned pregnancy, undiagnosed HIV infection, and lower treatment coverage at conception. During pregnancy, antiretroviral treatment, HIV suppression, and pregnancy outcomes are similar compared with older women. Earlier intervention strategies may provide additional benefits in the quality of care for women with HIV.
| Original language | English |
|---|---|
| Pages (from-to) | 2360-2365 |
| Number of pages | 6 |
| Journal | Epidemiology and Infection |
| Volume | 145 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Antiretroviral treatment
- HIV diagnosis
- HIV testing
- pregnancy
- women's health
ASJC Scopus subject areas
- Epidemiology
- Infectious Diseases
Cite this
Pregnant with HIV before age 25 : Data from a large national study in Italy, 2001-2016. / Floridia, M.; Masuelli, G.; Tamburrini, E.; Cetin, I.; Liuzzi, G.; Martinelli, P.; Guaraldi, G.; Spinillo, A.; Vimercati, A.; Maso, G.; Pinnetti, C.; Frisina, V.; Dalzero, S.; Ravizza, M.; Di Lorenzo, F.; Sterrantino, G.; Meli, M.; Campolmi, I.; Vichi, F.; Del Pin, B.; Marocco, R.; Mastroianni, C.; Mercurio, V. S.; Maccabruni, A.; Zaramella, M.; Mariani, B.; Nardini, G.; Stentarelli, C.; Beghetto, B.; Antoni, A. M.Degli; Molinari, A.; Crisalli, M. P.; Donisi, A.; Piepoli, M.; Cerri, V.; Zuccotti, G.; Giacomet, V.; Coletto, S.; Di Nello, F.; Madia, C.; Placido, G.; Milini, P.; Savalli, F.; Sabbatini, F.; Grossi, P.; Roccio, M.; Capone, A.; Amici, R.; Parazzini, F.; Vella, S.; The Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy.
In: Epidemiology and Infection, Vol. 145, No. 11, 01.08.2017, p. 2360-2365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pregnant with HIV before age 25
T2 - Data from a large national study in Italy, 2001-2016
AU - Floridia, M.
AU - Masuelli, G.
AU - Tamburrini, E.
AU - Cetin, I.
AU - Liuzzi, G.
AU - Martinelli, P.
AU - Guaraldi, G.
AU - Spinillo, A.
AU - Vimercati, A.
AU - Maso, G.
AU - Pinnetti, C.
AU - Frisina, V.
AU - Dalzero, S.
AU - Ravizza, M.
AU - Di Lorenzo, F.
AU - Sterrantino, G.
AU - Meli, M.
AU - Campolmi, I.
AU - Vichi, F.
AU - Del Pin, B.
AU - Marocco, R.
AU - Mastroianni, C.
AU - Mercurio, V. S.
AU - Maccabruni, A.
AU - Zaramella, M.
AU - Mariani, B.
AU - Nardini, G.
AU - Stentarelli, C.
AU - Beghetto, B.
AU - Antoni, A. M.Degli
AU - Molinari, A.
AU - Crisalli, M. P.
AU - Donisi, A.
AU - Piepoli, M.
AU - Cerri, V.
AU - Zuccotti, G.
AU - Giacomet, V.
AU - Coletto, S.
AU - Di Nello, F.
AU - Madia, C.
AU - Placido, G.
AU - Milini, P.
AU - Savalli, F.
AU - Sabbatini, F.
AU - Grossi, P.
AU - Roccio, M.
AU - Capone, A.
AU - Amici, R.
AU - Parazzini, F.
AU - Vella, S.
AU - The Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Young pregnant women with HIV may be at significant risk of unplanned pregnancy, lower treatment coverage, and other adverse pregnancy outcomes. In a large cohort of pregnant women with HIV in Italy, among 2979 pregnancies followed in 2001-2016, 9.0% were in women <25 years, with a significant increase over time (2001-2005: 7.0%; 2006-2010: 9.1%; 2011-2016: 12.2%, P < 0.001). Younger women had a lower rate of planned pregnancy (23.2% vs. 37.7%, odds ratio (OR) 0.50, 95% confidence interval (CI) 0.36-0.69), were more frequently diagnosed with HIV in pregnancy (46.5% vs. 20.9%, OR 3.29, 95% CI 2.54-4.25), and, if already diagnosed with HIV before pregnancy, were less frequently on antiretroviral treatment at conception (<25 years: 56.3%; ≥25 years: 69.0%, OR 0.58, 95% CI 0.41-0.81). During pregnancy, treatment coverage was almost universal in both age groups (98.5% vs. 99.3%), with no differences in rate of HIV viral suppression at third trimester and adverse pregnancy outcomes. The data show that young women represent a growing proportion of pregnant women with HIV, and are significantly more likely to have unplanned pregnancy, undiagnosed HIV infection, and lower treatment coverage at conception. During pregnancy, antiretroviral treatment, HIV suppression, and pregnancy outcomes are similar compared with older women. Earlier intervention strategies may provide additional benefits in the quality of care for women with HIV.
AB - Young pregnant women with HIV may be at significant risk of unplanned pregnancy, lower treatment coverage, and other adverse pregnancy outcomes. In a large cohort of pregnant women with HIV in Italy, among 2979 pregnancies followed in 2001-2016, 9.0% were in women <25 years, with a significant increase over time (2001-2005: 7.0%; 2006-2010: 9.1%; 2011-2016: 12.2%, P < 0.001). Younger women had a lower rate of planned pregnancy (23.2% vs. 37.7%, odds ratio (OR) 0.50, 95% confidence interval (CI) 0.36-0.69), were more frequently diagnosed with HIV in pregnancy (46.5% vs. 20.9%, OR 3.29, 95% CI 2.54-4.25), and, if already diagnosed with HIV before pregnancy, were less frequently on antiretroviral treatment at conception (<25 years: 56.3%; ≥25 years: 69.0%, OR 0.58, 95% CI 0.41-0.81). During pregnancy, treatment coverage was almost universal in both age groups (98.5% vs. 99.3%), with no differences in rate of HIV viral suppression at third trimester and adverse pregnancy outcomes. The data show that young women represent a growing proportion of pregnant women with HIV, and are significantly more likely to have unplanned pregnancy, undiagnosed HIV infection, and lower treatment coverage at conception. During pregnancy, antiretroviral treatment, HIV suppression, and pregnancy outcomes are similar compared with older women. Earlier intervention strategies may provide additional benefits in the quality of care for women with HIV.
KW - Antiretroviral treatment
KW - HIV diagnosis
KW - HIV testing
KW - pregnancy
KW - women's health
UR - http://www.scopus.com/inward/record.url?scp=85026872682&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026872682&partnerID=8YFLogxK
U2 - 10.1017/S0950268817001340
DO - 10.1017/S0950268817001340
M3 - Article
C2 - 28712385
AN - SCOPUS:85026872682
VL - 145
SP - 2360
EP - 2365
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 11
ER -