Preliminary definitions for the sonographic features of synovitis in children

Johannes Roth, Viviana Ravagnani, Marina Backhaus, Peter V. Balint, Alessandra Bruns, George A. Bruyn, Paz Collado, Lorenia De la Cruz, Severine Guillaume-Czitrom, Troels Herlin, Cristina Hernandez, Annamaria Iagnocco, Sandrine Jousse-Joulin, Stefano Lanni, Vibke Lilleby, Clara Malattia, Silvia Magni-Manzoni, Consuelo Modesto, Ana Narrodi, Juan Carlos Nieto & 12 others Sarah Ohrndorf, Linda Rossi, Anne-Marit Selvaag, Nanno Swen, Tracy Ting, Nikolay Tzaribachev, Patricia Vega-Fernandez, Jelena Vojinovic, Daniel Windschall, Maria Antonietta D'Agostino, Esperanza Naredo, OMERACT Ultrasound Group

Research output: Contribution to journalArticle

Abstract

Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalArthritis Care and Research
DOIs
Publication statusE-pub ahead of print - Oct 16 2016

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Synovitis
Ultrasonography
Synovial Membrane
Wrist
Arthritis
Exercise
Pediatrics
Pathology
Research

Keywords

  • Journal Article

Cite this

Roth, J., Ravagnani, V., Backhaus, M., Balint, P. V., Bruns, A., Bruyn, G. A., ... OMERACT Ultrasound Group (2016). Preliminary definitions for the sonographic features of synovitis in children. Arthritis Care and Research. https://doi.org/10.1002/acr.23130

Preliminary definitions for the sonographic features of synovitis in children. / Roth, Johannes; Ravagnani, Viviana; Backhaus, Marina; Balint, Peter V.; Bruns, Alessandra; Bruyn, George A.; Collado, Paz; De la Cruz, Lorenia; Guillaume-Czitrom, Severine; Herlin, Troels; Hernandez, Cristina; Iagnocco, Annamaria; Jousse-Joulin, Sandrine; Lanni, Stefano; Lilleby, Vibke; Malattia, Clara; Magni-Manzoni, Silvia; Modesto, Consuelo; Narrodi, Ana; Nieto, Juan Carlos; Ohrndorf, Sarah; Rossi, Linda; Selvaag, Anne-Marit; Swen, Nanno; Ting, Tracy; Tzaribachev, Nikolay; Vega-Fernandez, Patricia; Vojinovic, Jelena; Windschall, Daniel; D'Agostino, Maria Antonietta; Naredo, Esperanza; OMERACT Ultrasound Group.

In: Arthritis Care and Research, 16.10.2016.

Research output: Contribution to journalArticle

Roth, J, Ravagnani, V, Backhaus, M, Balint, PV, Bruns, A, Bruyn, GA, Collado, P, De la Cruz, L, Guillaume-Czitrom, S, Herlin, T, Hernandez, C, Iagnocco, A, Jousse-Joulin, S, Lanni, S, Lilleby, V, Malattia, C, Magni-Manzoni, S, Modesto, C, Narrodi, A, Nieto, JC, Ohrndorf, S, Rossi, L, Selvaag, A-M, Swen, N, Ting, T, Tzaribachev, N, Vega-Fernandez, P, Vojinovic, J, Windschall, D, D'Agostino, MA, Naredo, E & OMERACT Ultrasound Group 2016, 'Preliminary definitions for the sonographic features of synovitis in children', Arthritis Care and Research. https://doi.org/10.1002/acr.23130
Roth, Johannes ; Ravagnani, Viviana ; Backhaus, Marina ; Balint, Peter V. ; Bruns, Alessandra ; Bruyn, George A. ; Collado, Paz ; De la Cruz, Lorenia ; Guillaume-Czitrom, Severine ; Herlin, Troels ; Hernandez, Cristina ; Iagnocco, Annamaria ; Jousse-Joulin, Sandrine ; Lanni, Stefano ; Lilleby, Vibke ; Malattia, Clara ; Magni-Manzoni, Silvia ; Modesto, Consuelo ; Narrodi, Ana ; Nieto, Juan Carlos ; Ohrndorf, Sarah ; Rossi, Linda ; Selvaag, Anne-Marit ; Swen, Nanno ; Ting, Tracy ; Tzaribachev, Nikolay ; Vega-Fernandez, Patricia ; Vojinovic, Jelena ; Windschall, Daniel ; D'Agostino, Maria Antonietta ; Naredo, Esperanza ; OMERACT Ultrasound Group. / Preliminary definitions for the sonographic features of synovitis in children. In: Arthritis Care and Research. 2016.
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abstract = "Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80{\%} of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89{\%} (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research. This article is protected by copyright. All rights reserved.",
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author = "Johannes Roth and Viviana Ravagnani and Marina Backhaus and Balint, {Peter V.} and Alessandra Bruns and Bruyn, {George A.} and Paz Collado and {De la Cruz}, Lorenia and Severine Guillaume-Czitrom and Troels Herlin and Cristina Hernandez and Annamaria Iagnocco and Sandrine Jousse-Joulin and Stefano Lanni and Vibke Lilleby and Clara Malattia and Silvia Magni-Manzoni and Consuelo Modesto and Ana Narrodi and Nieto, {Juan Carlos} and Sarah Ohrndorf and Linda Rossi and Anne-Marit Selvaag and Nanno Swen and Tracy Ting and Nikolay Tzaribachev and Patricia Vega-Fernandez and Jelena Vojinovic and Daniel Windschall and D'Agostino, {Maria Antonietta} and Esperanza Naredo and {OMERACT Ultrasound Group}",
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T1 - Preliminary definitions for the sonographic features of synovitis in children

AU - Roth, Johannes

AU - Ravagnani, Viviana

AU - Backhaus, Marina

AU - Balint, Peter V.

AU - Bruns, Alessandra

AU - Bruyn, George A.

AU - Collado, Paz

AU - De la Cruz, Lorenia

AU - Guillaume-Czitrom, Severine

AU - Herlin, Troels

AU - Hernandez, Cristina

AU - Iagnocco, Annamaria

AU - Jousse-Joulin, Sandrine

AU - Lanni, Stefano

AU - Lilleby, Vibke

AU - Malattia, Clara

AU - Magni-Manzoni, Silvia

AU - Modesto, Consuelo

AU - Narrodi, Ana

AU - Nieto, Juan Carlos

AU - Ohrndorf, Sarah

AU - Rossi, Linda

AU - Selvaag, Anne-Marit

AU - Swen, Nanno

AU - Ting, Tracy

AU - Tzaribachev, Nikolay

AU - Vega-Fernandez, Patricia

AU - Vojinovic, Jelena

AU - Windschall, Daniel

AU - D'Agostino, Maria Antonietta

AU - Naredo, Esperanza

AU - OMERACT Ultrasound Group

N1 - © 2016, American College of Rheumatology.

PY - 2016/10/16

Y1 - 2016/10/16

N2 - Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research. This article is protected by copyright. All rights reserved.

AB - Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1002/acr.23130

DO - 10.1002/acr.23130

M3 - Article

JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association

JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association

SN - 0893-7524

ER -