Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries

A. M. Mileo; M. Fanuele; F. Battaglia; G. Scambia; C. Benedetti-Panici; E. Mattei; S. Mancuso; A. Delpino

Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries

A. M. Mileo, M. Fanuele, F. Battaglia, G. Scambia, C. Benedetti-Panici, E. Mattei, S. Mancuso, A. Delpino

Research output: Contribution to journal › Article › peer-review

Abstract

The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.

Original language	English
Pages (from-to)	114-118
Number of pages	5
Journal	International Journal of Biological Markers
Volume	7
Issue number	2
Publication status	Published - 1992

ASJC Scopus subject areas

Biochemistry
Immunology

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Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries. / Mileo, A. M.; Fanuele, M.; Battaglia, F.; Scambia, G.; Benedetti-Panici, C.; Mattei, E.; Mancuso, S.; Delpino, A.

In: International Journal of Biological Markers, Vol. 7, No. 2, 1992, p. 114-118.

Research output: Contribution to journal › Article › peer-review

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AU - Scambia, G.

AU - Benedetti-Panici, C.

AU - Mattei, E.

AU - Mancuso, S.

AU - Delpino, A.

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