Preliminary evaluation of in vivo reflectance confocal microscopy features of Kaposi's sarcoma

Thaís Corsetti Grazziotin, Carlo Cota, Rosana Bortoli Buffon, Leonardo Araújo Pinto, Alessandra Latini, Marco Ardigò

Research output: Contribution to journalArticle

Abstract

Background: Kaposi's sarcoma (KS) is an unusual, clinically polymorphic, vascular neoplasm with genetic, infectious, environmental and immunological pathogenesis. Reflectance confocal microscopy (RCM) made in vivo noninvasive imaging of the skin possible and has been used for the evaluation of several skin diseases offering important microscopic information. Objective: The purpose of our study is to describe the RCM features of KS and correlate them with histopathology evaluating the effective prediction attitude and repeatability of RCM. Methods: Twelve KS lesions underwent RCM followed by histological examination. Data obtained were statistically correlated. Results: Analysis of the incidence of 11 selected microscopic criteria (by RCM and optical histology: inflammatory cells in the epidermis and in the dermis, single or in aggregates; spindle cells; stroma; anastomosing, newborn, increased number and dilated vessels; extravasated erythrocytes; deposits of hemosiderin) was performed disclosing a good correlation and high sensitivity of RCM. Conclusion: In our study RCM seems to provide high accuracy to predict histological findings, demonstrating its possible role in the management of patients affected by KS.

Original languageEnglish
Pages (from-to)346-354
Number of pages9
JournalDermatology
Volume220
Issue number4
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Kaposi's sarcoma
  • Reflectance confocal microscopy

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Preliminary evaluation of in vivo reflectance confocal microscopy features of Kaposi's sarcoma'. Together they form a unique fingerprint.

  • Cite this