Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium

Anca Maria Cimpean, Mihai Poenaru Sava, Marius Raica, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Human pterygium is a benign fibrovascular outgrowth of the corneo-conjunctival junction, characterized by tissue remodeling, cellular proliferation, angiogenesis and inflam-mation. No data are available concerning the presence of lymphatic vessels in this pathological condition. The aim of this study was to evaluate by immunohistochemistry, using antibodies against D2-40, Prox-1 and Ki-67, the presence and the proliferative activity of lymphatic vessels in human pterygium. An increased lymphatic microvessel density was observed in the human pterygium compared to the normal conjunctiva. Moreover, D2-40-positive lymphatic endothelial cells were also actively proliferating, as assessed by Ki-67 immunostaining, while in normal conjunctiva proliferating lymphatic endothelial cells were not detectable. Overall, these data clearly indicate the presence of active proliferating lymphatic vessels in human pterygium, suggesting that active lymphangiogenesis occurs in this pathological condition.

Original languageEnglish
Pages (from-to)1111-1113
Number of pages3
JournalOncology Reports
Volume26
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • D2-40
  • Ki-67
  • Lymphangiogenesis
  • Lymphatic vessels
  • Prox-1
  • Pterygium

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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