Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis

Susan Nielsen, Nicolino Ruperto, Valeria Gerloni, Gabriele Simonini, Elisabetta Cortis, Loredana Lepore, Maria Giannina Alpigiani, Francesco Zulian, Fabrizia Corona, Maria Alessio, Roberto Barcellona, Romina Gallizzi, Federica Rossi, Silvia Magni-Manzoni, Giuseppina Lombardini, Giovanni Filocamo, Roberto Raschetti, Alberto Martini, Angelo Ravelli

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Methods: Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs. Results: A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression. Conclusion: Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalClinical and Experimental Rheumatology
Volume26
Issue number4
Publication statusPublished - Jul 2008

Keywords

  • Carpo-metacarpal ratio
  • Etanercept
  • Juvenile idiopathic arthritis
  • Radiographic progression
  • Tumor necrosis factor inhibitors

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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    Nielsen, S., Ruperto, N., Gerloni, V., Simonini, G., Cortis, E., Lepore, L., Alpigiani, M. G., Zulian, F., Corona, F., Alessio, M., Barcellona, R., Gallizzi, R., Rossi, F., Magni-Manzoni, S., Lombardini, G., Filocamo, G., Raschetti, R., Martini, A., & Ravelli, A. (2008). Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis. Clinical and Experimental Rheumatology, 26(4), 688-692.