Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis

Susan Nielsen, Nicolino Ruperto, Valeria Gerloni, Gabriele Simonini, Elisabetta Cortis, Loredana Lepore, Maria Giannina Alpigiani, Francesco Zulian, Fabrizia Corona, Maria Alessio, Roberto Barcellona, Romina Gallizzi, Federica Rossi, Silvia Magni-Manzoni, Giuseppina Lombardini, Giovanni Filocamo, Roberto Raschetti, Alberto Martini, Angelo Ravelli

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Methods: Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs. Results: A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression. Conclusion: Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalClinical and Experimental Rheumatology
Volume26
Issue number4
Publication statusPublished - Jul 2008

Fingerprint

Juvenile Arthritis
Pediatrics
Metacarpal Bones
Wrist
Registries
Hand
Joints
Therapeutics
Etanercept

Keywords

  • Carpo-metacarpal ratio
  • Etanercept
  • Juvenile idiopathic arthritis
  • Radiographic progression
  • Tumor necrosis factor inhibitors

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis. / Nielsen, Susan; Ruperto, Nicolino; Gerloni, Valeria; Simonini, Gabriele; Cortis, Elisabetta; Lepore, Loredana; Alpigiani, Maria Giannina; Zulian, Francesco; Corona, Fabrizia; Alessio, Maria; Barcellona, Roberto; Gallizzi, Romina; Rossi, Federica; Magni-Manzoni, Silvia; Lombardini, Giuseppina; Filocamo, Giovanni; Raschetti, Roberto; Martini, Alberto; Ravelli, Angelo.

In: Clinical and Experimental Rheumatology, Vol. 26, No. 4, 07.2008, p. 688-692.

Research output: Contribution to journalArticle

Nielsen, S, Ruperto, N, Gerloni, V, Simonini, G, Cortis, E, Lepore, L, Alpigiani, MG, Zulian, F, Corona, F, Alessio, M, Barcellona, R, Gallizzi, R, Rossi, F, Magni-Manzoni, S, Lombardini, G, Filocamo, G, Raschetti, R, Martini, A & Ravelli, A 2008, 'Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis', Clinical and Experimental Rheumatology, vol. 26, no. 4, pp. 688-692.
Nielsen, Susan ; Ruperto, Nicolino ; Gerloni, Valeria ; Simonini, Gabriele ; Cortis, Elisabetta ; Lepore, Loredana ; Alpigiani, Maria Giannina ; Zulian, Francesco ; Corona, Fabrizia ; Alessio, Maria ; Barcellona, Roberto ; Gallizzi, Romina ; Rossi, Federica ; Magni-Manzoni, Silvia ; Lombardini, Giuseppina ; Filocamo, Giovanni ; Raschetti, Roberto ; Martini, Alberto ; Ravelli, Angelo. / Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis. In: Clinical and Experimental Rheumatology. 2008 ; Vol. 26, No. 4. pp. 688-692.
@article{d1d0cccf92534172b949017da4b65885,
title = "Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis",
abstract = "Objective: To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Methods: Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs. Results: A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77{\%}, 72{\%}, and 50{\%}, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression. Conclusion: Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.",
keywords = "Carpo-metacarpal ratio, Etanercept, Juvenile idiopathic arthritis, Radiographic progression, Tumor necrosis factor inhibitors",
author = "Susan Nielsen and Nicolino Ruperto and Valeria Gerloni and Gabriele Simonini and Elisabetta Cortis and Loredana Lepore and Alpigiani, {Maria Giannina} and Francesco Zulian and Fabrizia Corona and Maria Alessio and Roberto Barcellona and Romina Gallizzi and Federica Rossi and Silvia Magni-Manzoni and Giuseppina Lombardini and Giovanni Filocamo and Roberto Raschetti and Alberto Martini and Angelo Ravelli",
year = "2008",
month = "7",
language = "English",
volume = "26",
pages = "688--692",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "4",

}

TY - JOUR

T1 - Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis

AU - Nielsen, Susan

AU - Ruperto, Nicolino

AU - Gerloni, Valeria

AU - Simonini, Gabriele

AU - Cortis, Elisabetta

AU - Lepore, Loredana

AU - Alpigiani, Maria Giannina

AU - Zulian, Francesco

AU - Corona, Fabrizia

AU - Alessio, Maria

AU - Barcellona, Roberto

AU - Gallizzi, Romina

AU - Rossi, Federica

AU - Magni-Manzoni, Silvia

AU - Lombardini, Giuseppina

AU - Filocamo, Giovanni

AU - Raschetti, Roberto

AU - Martini, Alberto

AU - Ravelli, Angelo

PY - 2008/7

Y1 - 2008/7

N2 - Objective: To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Methods: Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs. Results: A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression. Conclusion: Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.

AB - Objective: To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Methods: Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs. Results: A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression. Conclusion: Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.

KW - Carpo-metacarpal ratio

KW - Etanercept

KW - Juvenile idiopathic arthritis

KW - Radiographic progression

KW - Tumor necrosis factor inhibitors

UR - http://www.scopus.com/inward/record.url?scp=52649108201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649108201&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 688

EP - 692

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 4

ER -