Preliminary evidence that vortioxetine may improve sleep quality in depressed patients with insomnia

a retrospective questionnaire analysis

C. Liguori, L. Ferini-Strambi, F. Izzi, L. Mari, N. Manfredi, A. D'Elia, N. B. Mercuri, F. Placidi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Insomnia is a frequent symptom in depressed patients. It can present with difficulty in initiating and/or maintaining sleep. We retrospectively evaluated a group of 15 patients affected by major depressive disorder and complaining of insomnia, who started vortioxetine (VOR) treatment for their depressive symptoms. The following questionnaires were captured at baseline and follow-up: Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Beck Depression Inventory. Pittsburgh Sleep Quality Index total score significantly decreased between follow-up and baseline (P < 0.01), and in several subitems related to sleep quality and continuity. Moreover, Epworth Sleepiness Scale decreased between follow-up and baseline (P < 0.01). Finally, Beck Depression Inventory reduction was also evident between follow-up and baseline (P < 0.01). This retrospective analysis showing the significant effect of VOR on both depressive symptoms and insomnia in patients showing comorbid major depressive disorder and insomnia invites further research in order to confirm this preliminary evidence. We hypothesize that the VOR mechanism of action may explain the improvement of subjective sleep, other than depressive symptoms.

Original languageEnglish
JournalBritish Journal of Clinical Pharmacology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Sleep Initiation and Maintenance Disorders
Sleep
Depression
Major Depressive Disorder
Equipment and Supplies
vortioxetine
Surveys and Questionnaires
Research

Keywords

  • daytime sleepiness
  • depression
  • insomnia
  • subjective sleep
  • vortioxetine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

@article{25394f7295ce4c1f869e2052953f693b,
title = "Preliminary evidence that vortioxetine may improve sleep quality in depressed patients with insomnia: a retrospective questionnaire analysis",
abstract = "Insomnia is a frequent symptom in depressed patients. It can present with difficulty in initiating and/or maintaining sleep. We retrospectively evaluated a group of 15 patients affected by major depressive disorder and complaining of insomnia, who started vortioxetine (VOR) treatment for their depressive symptoms. The following questionnaires were captured at baseline and follow-up: Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Beck Depression Inventory. Pittsburgh Sleep Quality Index total score significantly decreased between follow-up and baseline (P < 0.01), and in several subitems related to sleep quality and continuity. Moreover, Epworth Sleepiness Scale decreased between follow-up and baseline (P < 0.01). Finally, Beck Depression Inventory reduction was also evident between follow-up and baseline (P < 0.01). This retrospective analysis showing the significant effect of VOR on both depressive symptoms and insomnia in patients showing comorbid major depressive disorder and insomnia invites further research in order to confirm this preliminary evidence. We hypothesize that the VOR mechanism of action may explain the improvement of subjective sleep, other than depressive symptoms.",
keywords = "daytime sleepiness, depression, insomnia, subjective sleep, vortioxetine",
author = "C. Liguori and L. Ferini-Strambi and F. Izzi and L. Mari and N. Manfredi and A. D'Elia and Mercuri, {N. B.} and F. Placidi",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/bcp.13772",
language = "English",
journal = "British Journal of Clinical Pharmacology",
issn = "0306-5251",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Preliminary evidence that vortioxetine may improve sleep quality in depressed patients with insomnia

T2 - a retrospective questionnaire analysis

AU - Liguori, C.

AU - Ferini-Strambi, L.

AU - Izzi, F.

AU - Mari, L.

AU - Manfredi, N.

AU - D'Elia, A.

AU - Mercuri, N. B.

AU - Placidi, F.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Insomnia is a frequent symptom in depressed patients. It can present with difficulty in initiating and/or maintaining sleep. We retrospectively evaluated a group of 15 patients affected by major depressive disorder and complaining of insomnia, who started vortioxetine (VOR) treatment for their depressive symptoms. The following questionnaires were captured at baseline and follow-up: Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Beck Depression Inventory. Pittsburgh Sleep Quality Index total score significantly decreased between follow-up and baseline (P < 0.01), and in several subitems related to sleep quality and continuity. Moreover, Epworth Sleepiness Scale decreased between follow-up and baseline (P < 0.01). Finally, Beck Depression Inventory reduction was also evident between follow-up and baseline (P < 0.01). This retrospective analysis showing the significant effect of VOR on both depressive symptoms and insomnia in patients showing comorbid major depressive disorder and insomnia invites further research in order to confirm this preliminary evidence. We hypothesize that the VOR mechanism of action may explain the improvement of subjective sleep, other than depressive symptoms.

AB - Insomnia is a frequent symptom in depressed patients. It can present with difficulty in initiating and/or maintaining sleep. We retrospectively evaluated a group of 15 patients affected by major depressive disorder and complaining of insomnia, who started vortioxetine (VOR) treatment for their depressive symptoms. The following questionnaires were captured at baseline and follow-up: Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Beck Depression Inventory. Pittsburgh Sleep Quality Index total score significantly decreased between follow-up and baseline (P < 0.01), and in several subitems related to sleep quality and continuity. Moreover, Epworth Sleepiness Scale decreased between follow-up and baseline (P < 0.01). Finally, Beck Depression Inventory reduction was also evident between follow-up and baseline (P < 0.01). This retrospective analysis showing the significant effect of VOR on both depressive symptoms and insomnia in patients showing comorbid major depressive disorder and insomnia invites further research in order to confirm this preliminary evidence. We hypothesize that the VOR mechanism of action may explain the improvement of subjective sleep, other than depressive symptoms.

KW - daytime sleepiness

KW - depression

KW - insomnia

KW - subjective sleep

KW - vortioxetine

UR - http://www.scopus.com/inward/record.url?scp=85055473324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055473324&partnerID=8YFLogxK

U2 - 10.1111/bcp.13772

DO - 10.1111/bcp.13772

M3 - Article

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

SN - 0306-5251

ER -