Preliminary outcomes after transcatheter aortic valve implantation in patients with systemic sclerosis

Chiara Bernelli, Alaide Chieffo, Gennaro Giustino, Matteo Montorfano, Azeem Latib, Vasileios F. Panoulas, Remo D aniel Covello, Eustachio Agricola, Pietro Spagnolo, Ottavio Alfieri, Antonio Colombo, Micaela Cioni

Research output: Contribution to journalArticle

Abstract

AIMS: The aim of this study was to report the feasibility and the preliminary outcomes after transcatheter aortic valve implantation (TAVI) in the frail and unique high-risk population of patients with systemic sclerosis (SSc) and severe aortic stenosis (AS).

METHODS AND RESULTS: All patients with SSc and severe AS treated with TAVI between November 2007 and June 2013 in our centre were included in the current study. Outcomes were assessed using the Valve Academic Research Consortium 2 (VARC-2) definitions. Of 526 surgical high-risk patients treated in the study period, only six had SSc (1.1%). All SSc patients underwent transfemoral TAVI under conscious sedation. The procedure was successfully performed in all patients. There was one case of a major vascular complication. During a median follow-up time of 550 days (interquartile range 390-1,009 days), five of the six patients were alive, free from any complications and with an NYHA Class I or II. One patient died at 670 days from a stroke of unknown aetiology.

CONCLUSIONS: The present case series suggests that the TAVI procedure is feasible in patients with SSc and severe AS.

Original languageEnglish
Pages (from-to)1464-1467
Number of pages4
JournalEuroIntervention
Volume10
Issue number12
DOIs
Publication statusPublished - Apr 1 2015

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Systemic Scleroderma
Aortic Valve Stenosis
Conscious Sedation
Transcatheter Aortic Valve Replacement
Blood Vessels
Stroke
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

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Preliminary outcomes after transcatheter aortic valve implantation in patients with systemic sclerosis. / Bernelli, Chiara; Chieffo, Alaide; Giustino, Gennaro; Montorfano, Matteo; Latib, Azeem; Panoulas, Vasileios F.; Covello, Remo D aniel; Agricola, Eustachio; Spagnolo, Pietro; Alfieri, Ottavio; Colombo, Antonio; Cioni, Micaela.

In: EuroIntervention, Vol. 10, No. 12, 01.04.2015, p. 1464-1467.

Research output: Contribution to journalArticle

Bernelli, C, Chieffo, A, Giustino, G, Montorfano, M, Latib, A, Panoulas, VF, Covello, RDA, Agricola, E, Spagnolo, P, Alfieri, O, Colombo, A & Cioni, M 2015, 'Preliminary outcomes after transcatheter aortic valve implantation in patients with systemic sclerosis', EuroIntervention, vol. 10, no. 12, pp. 1464-1467. https://doi.org/10.4244/EIJV10I12A255
Bernelli, Chiara ; Chieffo, Alaide ; Giustino, Gennaro ; Montorfano, Matteo ; Latib, Azeem ; Panoulas, Vasileios F. ; Covello, Remo D aniel ; Agricola, Eustachio ; Spagnolo, Pietro ; Alfieri, Ottavio ; Colombo, Antonio ; Cioni, Micaela. / Preliminary outcomes after transcatheter aortic valve implantation in patients with systemic sclerosis. In: EuroIntervention. 2015 ; Vol. 10, No. 12. pp. 1464-1467.
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