Preliminary results for positron emission mammography: Real-time functional breast imaging in a conventional mammography gantry

Irving Weinberg, Stan Majewski, Andrew Weisenberger, Allen Markowitz, Luigi Aloj, Lukasz Majewski, David Danforth, James Mulshine, Kenneth Cowan, Joanne Zujewski, Catherine Chow, Elizabeth Jones, Victoria Chang, Wendie Berg, Joseph Frank

Research output: Contribution to journalArticle

Abstract

In order to optimally integrate radiotracer breast imaging within the breast clinic, anatomy and pathology should be easily correlated with functional nuclear medicine breast images. As a first step in the development of a hybrid functional/anatomic breast imaging platform with biopsy capability, a conventional X-ray mammography gantry was modified to image the compressed breast with positron emitters. Phantom studies with the positron emission mammography (PEM) device showed that a 1-cc hot spot could be detected within 5 min. A preliminary clinical trial demonstrated in vivo visualization of primary breast cancer within 4 min. For sites where positron-emitting radionuclides are available, PEM promises to achieve low-cost directed functional examination of breast abnormalities, with the potential for achieving X-ray correlation and image-guided biopsy.

Original languageEnglish
Pages (from-to)804-806
Number of pages3
JournalEuropean Journal Of Nuclear Medicine
Volume23
Issue number7
DOIs
Publication statusPublished - 1996

Keywords

  • Breast
  • Cancer
  • Fluorine-18 2-deoxy-2-fluoro-D-glucose
  • Mammography
  • Positron

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Weinberg, I., Majewski, S., Weisenberger, A., Markowitz, A., Aloj, L., Majewski, L., Danforth, D., Mulshine, J., Cowan, K., Zujewski, J., Chow, C., Jones, E., Chang, V., Berg, W., & Frank, J. (1996). Preliminary results for positron emission mammography: Real-time functional breast imaging in a conventional mammography gantry. European Journal Of Nuclear Medicine, 23(7), 804-806. https://doi.org/10.1007/BF00843710