Preliminary results of contrast-enhanced sonography in the evaluation of the response of uveal melanoma to gamma-knife radiosurgery

Massimo Venturini, Caterina Colantoni, Giulio Modorati, Maura Di Nicola, Annalisa Colucci, Giulia Agostini, Piero Picozzi, Francesco De Cobelli, Giorgio Parmiani, Pietro Mortini, Francesco Bandello, Alessandro Del Maschio

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Our aim was to prospectively analyze the use of contrast-enhanced ultrasound (CEUS) in the quantitative assessment of the response of uveal melanoma (UM) to gamma-knife radiosurgery (GKR), investigating whether changes in tumor vascularization precede thickness reduction, which on average occurs at 12 months after GKR. Methods: Ten patients with UM treated with GKR underwent sonography (US) and CEUS at baseline and at 3, 6, and 12 months after GKR. The transverse diameter, thickness, and quantitative parameters of the UM (ie, area under the curve in the wash-in phase, wash-in perfusion index, peak enhancement, and wash-in rate) were calculated by using dedicated software and compared by using Wilcoxon's signed-rank test. Results: The mean tumor thickness on US was significantly less at both 6 (6.6 mm) and 12 months after GKR (5.8 mm) than it was at baseline (8.3 mm; p6; 6 months after GKR, it was 2 × 101 (p1 (p <0.05). The wash-in rate (in au) at baseline was 1 × 106; 6 months after GKR, it was 2.1 (p7; 6 months after GKR, it was 7 × 101 (p2 (p8; 12 months after GKR, it was reduced to 6 × 102 (p

Original languageEnglish
Pages (from-to)421-430
Number of pages10
JournalJournal of Clinical Ultrasound
Volume43
Issue number7
DOIs
Publication statusPublished - 2015

Fingerprint

Radiosurgery
Ultrasonography
Uveal melanoma
Nonparametric Statistics
Area Under Curve
Neoplasms
Software
Perfusion

Keywords

  • Contrast-enhanced ultrasonography
  • Gamma-knife radiosurgery
  • Ultrasonography
  • Uveal melanoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Preliminary results of contrast-enhanced sonography in the evaluation of the response of uveal melanoma to gamma-knife radiosurgery. / Venturini, Massimo; Colantoni, Caterina; Modorati, Giulio; Di Nicola, Maura; Colucci, Annalisa; Agostini, Giulia; Picozzi, Piero; De Cobelli, Francesco; Parmiani, Giorgio; Mortini, Pietro; Bandello, Francesco; Del Maschio, Alessandro.

In: Journal of Clinical Ultrasound, Vol. 43, No. 7, 2015, p. 421-430.

Research output: Contribution to journalArticle

@article{3a9fecfcfdcf42dda8c403534ebc42ea,
title = "Preliminary results of contrast-enhanced sonography in the evaluation of the response of uveal melanoma to gamma-knife radiosurgery",
abstract = "Purpose: Our aim was to prospectively analyze the use of contrast-enhanced ultrasound (CEUS) in the quantitative assessment of the response of uveal melanoma (UM) to gamma-knife radiosurgery (GKR), investigating whether changes in tumor vascularization precede thickness reduction, which on average occurs at 12 months after GKR. Methods: Ten patients with UM treated with GKR underwent sonography (US) and CEUS at baseline and at 3, 6, and 12 months after GKR. The transverse diameter, thickness, and quantitative parameters of the UM (ie, area under the curve in the wash-in phase, wash-in perfusion index, peak enhancement, and wash-in rate) were calculated by using dedicated software and compared by using Wilcoxon's signed-rank test. Results: The mean tumor thickness on US was significantly less at both 6 (6.6 mm) and 12 months after GKR (5.8 mm) than it was at baseline (8.3 mm; p6; 6 months after GKR, it was 2 × 101 (p1 (p <0.05). The wash-in rate (in au) at baseline was 1 × 106; 6 months after GKR, it was 2.1 (p7; 6 months after GKR, it was 7 × 101 (p2 (p8; 12 months after GKR, it was reduced to 6 × 102 (p",
keywords = "Contrast-enhanced ultrasonography, Gamma-knife radiosurgery, Ultrasonography, Uveal melanoma",
author = "Massimo Venturini and Caterina Colantoni and Giulio Modorati and {Di Nicola}, Maura and Annalisa Colucci and Giulia Agostini and Piero Picozzi and {De Cobelli}, Francesco and Giorgio Parmiani and Pietro Mortini and Francesco Bandello and {Del Maschio}, Alessandro",
year = "2015",
doi = "10.1002/jcu.22262",
language = "English",
volume = "43",
pages = "421--430",
journal = "Journal of Clinical Ultrasound",
issn = "0091-2751",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Preliminary results of contrast-enhanced sonography in the evaluation of the response of uveal melanoma to gamma-knife radiosurgery

AU - Venturini, Massimo

AU - Colantoni, Caterina

AU - Modorati, Giulio

AU - Di Nicola, Maura

AU - Colucci, Annalisa

AU - Agostini, Giulia

AU - Picozzi, Piero

AU - De Cobelli, Francesco

AU - Parmiani, Giorgio

AU - Mortini, Pietro

AU - Bandello, Francesco

AU - Del Maschio, Alessandro

PY - 2015

Y1 - 2015

N2 - Purpose: Our aim was to prospectively analyze the use of contrast-enhanced ultrasound (CEUS) in the quantitative assessment of the response of uveal melanoma (UM) to gamma-knife radiosurgery (GKR), investigating whether changes in tumor vascularization precede thickness reduction, which on average occurs at 12 months after GKR. Methods: Ten patients with UM treated with GKR underwent sonography (US) and CEUS at baseline and at 3, 6, and 12 months after GKR. The transverse diameter, thickness, and quantitative parameters of the UM (ie, area under the curve in the wash-in phase, wash-in perfusion index, peak enhancement, and wash-in rate) were calculated by using dedicated software and compared by using Wilcoxon's signed-rank test. Results: The mean tumor thickness on US was significantly less at both 6 (6.6 mm) and 12 months after GKR (5.8 mm) than it was at baseline (8.3 mm; p6; 6 months after GKR, it was 2 × 101 (p1 (p <0.05). The wash-in rate (in au) at baseline was 1 × 106; 6 months after GKR, it was 2.1 (p7; 6 months after GKR, it was 7 × 101 (p2 (p8; 12 months after GKR, it was reduced to 6 × 102 (p

AB - Purpose: Our aim was to prospectively analyze the use of contrast-enhanced ultrasound (CEUS) in the quantitative assessment of the response of uveal melanoma (UM) to gamma-knife radiosurgery (GKR), investigating whether changes in tumor vascularization precede thickness reduction, which on average occurs at 12 months after GKR. Methods: Ten patients with UM treated with GKR underwent sonography (US) and CEUS at baseline and at 3, 6, and 12 months after GKR. The transverse diameter, thickness, and quantitative parameters of the UM (ie, area under the curve in the wash-in phase, wash-in perfusion index, peak enhancement, and wash-in rate) were calculated by using dedicated software and compared by using Wilcoxon's signed-rank test. Results: The mean tumor thickness on US was significantly less at both 6 (6.6 mm) and 12 months after GKR (5.8 mm) than it was at baseline (8.3 mm; p6; 6 months after GKR, it was 2 × 101 (p1 (p <0.05). The wash-in rate (in au) at baseline was 1 × 106; 6 months after GKR, it was 2.1 (p7; 6 months after GKR, it was 7 × 101 (p2 (p8; 12 months after GKR, it was reduced to 6 × 102 (p

KW - Contrast-enhanced ultrasonography

KW - Gamma-knife radiosurgery

KW - Ultrasonography

KW - Uveal melanoma

UR - http://www.scopus.com/inward/record.url?scp=84948387792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948387792&partnerID=8YFLogxK

U2 - 10.1002/jcu.22262

DO - 10.1002/jcu.22262

M3 - Article

VL - 43

SP - 421

EP - 430

JO - Journal of Clinical Ultrasound

JF - Journal of Clinical Ultrasound

SN - 0091-2751

IS - 7

ER -