Preliminary results of contrast-enhanced sonography in the evaluation of the response of uveal melanoma to gamma-knife radiosurgery

Massimo Venturini, Caterina Colantoni, Giulio Modorati, Maura Di Nicola, Annalisa Colucci, Giulia Agostini, Piero Picozzi, Francesco De Cobelli, Giorgio Parmiani, Pietro Mortini, Francesco Bandello, Alessandro Del Maschio

Research output: Contribution to journalArticle


Purpose: Our aim was to prospectively analyze the use of contrast-enhanced ultrasound (CEUS) in the quantitative assessment of the response of uveal melanoma (UM) to gamma-knife radiosurgery (GKR), investigating whether changes in tumor vascularization precede thickness reduction, which on average occurs at 12 months after GKR. Methods: Ten patients with UM treated with GKR underwent sonography (US) and CEUS at baseline and at 3, 6, and 12 months after GKR. The transverse diameter, thickness, and quantitative parameters of the UM (ie, area under the curve in the wash-in phase, wash-in perfusion index, peak enhancement, and wash-in rate) were calculated by using dedicated software and compared by using Wilcoxon's signed-rank test. Results: The mean tumor thickness on US was significantly less at both 6 (6.6 mm) and 12 months after GKR (5.8 mm) than it was at baseline (8.3 mm; p6; 6 months after GKR, it was 2 × 101 (p1 (p <0.05). The wash-in rate (in au) at baseline was 1 × 106; 6 months after GKR, it was 2.1 (p7; 6 months after GKR, it was 7 × 101 (p2 (p8; 12 months after GKR, it was reduced to 6 × 102 (p

Original languageEnglish
Pages (from-to)421-430
Number of pages10
JournalJournal of Clinical Ultrasound
Issue number7
Publication statusPublished - 2015



  • Contrast-enhanced ultrasonography
  • Gamma-knife radiosurgery
  • Ultrasonography
  • Uveal melanoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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