RISULTATI PRELIMINARI DELL'ASSOCIAZIONE INTERFERONE ALFA 2A RICOMBINANTE E VINBLASTINA NELLA TERAPIA ADIUVANTE DEL CARCINOMA RENALE IN STADIO LOCALMENTE AVANZATO

Translated title of the contribution: Preliminary results of the association recombinant alpha 2a-interferon and vinblastine in the adjuvant therapy of renal carcinoma in the locally advanced stage

F. P. Selvaggi, M. Battaglia, A. Traficante, G. Disabato, G. A. Saracino, P. Ditonno, A. Guarini, V. Pavone, S. Capalbo, A. Mileti

Research output: Contribution to journalArticle

Abstract

Overall survival for renal cell carcinoma after radical nephrectomy is 50% at 5 years. This poor prognosis is related especially to the stage of disease, having a major predictor of progression, positive lymph nodes or a tumor beyond the renal capsule. In this study, the role has been investigated of adjuvant therapy with Interferon or Interferon + Vinblastine to decrease the risk of progression. Preliminary results on the toxicity of this regimen are presented. Of 12 patients treated (6 with Interferon and 6 with Interferon + Vinblastine), none reached WHO grade 3 toxicity. Major side effects were leukopenia, paraesthesia, fever, chills and headache, resolved with medical treatment or suspension therapy. However, regimen interruption was never prolonged over 3 weeks. It is concluded that this form of adjvuant regimen is tolerable and can be safety administered in patients with advanced renal cell carcinoma.

Translated title of the contributionPreliminary results of the association recombinant alpha 2a-interferon and vinblastine in the adjuvant therapy of renal carcinoma in the locally advanced stage
Original languageItalian
Pages (from-to)123-125
Number of pages3
JournalActa Urologica Italica
Volume6
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Urology

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    Selvaggi, F. P., Battaglia, M., Traficante, A., Disabato, G., Saracino, G. A., Ditonno, P., Guarini, A., Pavone, V., Capalbo, S., & Mileti, A. (1992). RISULTATI PRELIMINARI DELL'ASSOCIAZIONE INTERFERONE ALFA 2A RICOMBINANTE E VINBLASTINA NELLA TERAPIA ADIUVANTE DEL CARCINOMA RENALE IN STADIO LOCALMENTE AVANZATO. Acta Urologica Italica, 6(2), 123-125.