Preliminary study of metabolic radiotherapy with 188Re via small animal imaging

A. Antoccia, G. Baldazzi, M. Bello, D. Bernardini, P. Boccaccio, D. Bollini, F. de Notaristefani, F. Garibaldi, G. Hull, U. Mazzi, G. Moschini, A. Muciaccio, F. L. Navarria, V. Orsolini Cencelli, G. Pancaldi, R. Pani, A. Perrotta, M. Riondato, A. Rosato, A. SguraC. Tanzarella, N. Uzunov, M. Zuffa

Research output: Contribution to journalArticle

Abstract

188Re is a β- (Emax = 2.12 = MeV) and γ (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, 99mTc, molecules of hyaluronic acid (HA) have been labelled with 188Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6 × 0.6 × 10 mm3 pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of 188Re and with C57 black mice injected with the 188Re-HA solution are presented. To increase the space resolution and to obtain two orthogonal projections simultaneously we are building in parallel two new cameras to be positioned at 90 degrees. They use a CsI(Tl) matrix with 1 × 1 × 5 mm3 pixels read out by H8500 Hamamatsu Flat panel PMT.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalNuclear Physics B - Proceedings Supplements
Volume150
Issue number1-3
DOIs
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Nuclear and High Energy Physics

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    Antoccia, A., Baldazzi, G., Bello, M., Bernardini, D., Boccaccio, P., Bollini, D., de Notaristefani, F., Garibaldi, F., Hull, G., Mazzi, U., Moschini, G., Muciaccio, A., Navarria, F. L., Orsolini Cencelli, V., Pancaldi, G., Pani, R., Perrotta, A., Riondato, M., Rosato, A., ... Zuffa, M. (2006). Preliminary study of metabolic radiotherapy with 188Re via small animal imaging. Nuclear Physics B - Proceedings Supplements, 150(1-3), 411-416. https://doi.org/10.1016/j.nuclphysbps.2005.02.111