@article{479b28550aeb47579bf63c2621cb39a6,
title = "Preliminary validation of the digital ulcer clinical assessment score in systemic sclerosis",
abstract = "Objective. To date, “healed/non-healed” and clinical judgment are the only available assessment tools for digital ulcers (DU) in patients with systemic sclerosis (SSc). The aim of our study is to examine a preliminary composite DU clinical assessment score (DUCAS) for SSc for face, content, and construct validity. Methods. Patients with SSc presenting at least 1 finger DU were enrolled and assessed with the Health Assessment Questionnaire-Disability Index, Cochin scale, visual analog scale (VAS) for DU-related pain, patient global DU status, and global assessment as patient-reported outcomes (PRO), and physician VAS for DU status (phyGDU) as an SSc-DU expert physician/nurse measure. The DUCAS included 7 DU-related variables selected by a committee of SSc DU experts and weighted on a clinical basis. Face validity was examined by consensus and partial construct validity was tested through convergent correlation with other measures of hand function, using Spearman's correlations. A range of patients with SSc was examined. A linear regression model with backward stepwise analysis was used to determine the relationship of individual variables with the primary clinical parameter, phyGDU. Results. Forty-four patients with SSc (9 males, mean age 55 ± 15 yrs, mean disease duration 9.9 ± 5.8 yrs) were enrolled in the study. Overall DUCAS showed significant positive correlations with all abovementioned PRO (r > 0.4, p < 0.01). When all scores and scales were modeled, only DUCAS significantly predicted phyGDU (r = 0.59, R2 = 0.354, Akaike information criterion = 385.4). Conclusion. Preliminarily, we suggest that the DUCAS may be a new clinical score for SSc-related DU, having face and content validity and convergent/divergent correlations (construct validity). These early data suggest that this score deserves further evaluation. {\textcopyright} 2019 Journal of Rheumatology. All rights reserved.",
keywords = "Digital Ulcer, Disease Activity Score, Outcome Measures Wounds and Injuries, Systemic Sclerosis, adult, aged, Article, clinical article, clinical assessment tool, controlled study, correlation coefficient, correlational study, digital ulcer clinical assessment score, disease duration, face validity, female, finger ulcer, hand function, human, linear regression analysis, male, patient-reported outcome, priority journal, questionnaire, scoring system, systemic sclerosis, visual analog scale",
author = "C. Bruni and T. Ngcozana and F. Braschi and T. Pucci and G. Piemonte and L. Benelli and M. Poli and Y.A. Suliman and S. Guiducci and S. Bellando-Randone and S. Balduzzi and J. Grotts and C.P. Denton and L. Rasero and C. Montecucco and D.E. Furst and M. Matucci-Cerinic",
note = "Cited By :1 Export Date: 10 October 2019 CODEN: JRHUA Correspondence Address: Bruni, C.; Department of Experimental and Clinical Medicine, Department of Public Health, University of FlorenceItaly; email: cosimobruni85@gmail.com Funding details: University of California Funding details: Center for Outcomes Research and Evaluation, Yale School of Medicine Funding details: California Department of Public Health Funding details: Fondazione IRCCS Policlinico San Matteo Funding details: University College London, UCL Funding details: Novartis Funding details: Foundation for the National Institutes of Health Funding details: British Microcirculation Society Funding details: Pfizer Funding details: European League Against Rheumatism Funding text 1: From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Funding text 2: Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. 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year = "2019",
doi = "10.3899/jrheum.171486",
language = "English",
volume = "46",
pages = "603--608",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "6",
}