Abstract
Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.
| Original language | English |
|---|---|
| Pages (from-to) | 325-330 |
| Number of pages | 6 |
| Journal | Neurobiology of Aging |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1996 |
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Keywords
- brain imaging
- EEG
- MRI
- PET
- SPECT
- Werner's syndrome
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Premature aging in Werner's syndrome spares the central nervous system. / Postiglione, Alfredo; Soricelli, Andrea; Covelli, Eugenio M.; Iazzetta, Nicolangelo; Ruocco, Antonio; Milan, Graziella; Santoro, Lucio; Alfano, Bruno; Brunetti, Arturo.
In: Neurobiology of Aging, Vol. 17, No. 3, 05.1996, p. 325-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Premature aging in Werner's syndrome spares the central nervous system
AU - Postiglione, Alfredo
AU - Soricelli, Andrea
AU - Covelli, Eugenio M.
AU - Iazzetta, Nicolangelo
AU - Ruocco, Antonio
AU - Milan, Graziella
AU - Santoro, Lucio
AU - Alfano, Bruno
AU - Brunetti, Arturo
PY - 1996/5
Y1 - 1996/5
N2 - Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.
AB - Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.
KW - brain imaging
KW - EEG
KW - MRI
KW - PET
KW - SPECT
KW - Werner's syndrome
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U2 - 10.1016/0197-4580(96)00033-4
DO - 10.1016/0197-4580(96)00033-4
M3 - Article
VL - 17
SP - 325
EP - 330
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 3
ER -