Premature aging in Werner's syndrome spares the central nervous system

Alfredo Postiglione, Andrea Soricelli, Eugenio M. Covelli, Nicolangelo Iazzetta, Antonio Ruocco, Graziella Milan, Lucio Santoro, Bruno Alfano, Arturo Brunetti

Research output: Contribution to journalArticlepeer-review


Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNeurobiology of Aging
Issue number3
Publication statusPublished - May 1996


  • brain imaging
  • EEG
  • MRI
  • PET
  • Werner's syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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