Premature aging in Werner's syndrome spares the central nervous system

Alfredo Postiglione; Andrea Soricelli; Eugenio M. Covelli; Nicolangelo Iazzetta; Antonio Ruocco; Graziella Milan; Lucio Santoro; Bruno Alfano; Arturo Brunetti

doi:10.1016/0197-4580(96)00033-4

Premature aging in Werner's syndrome spares the central nervous system

Alfredo Postiglione, Andrea Soricelli, Eugenio M. Covelli, Nicolangelo Iazzetta, Antonio Ruocco, Graziella Milan, Lucio Santoro, Bruno Alfano, Arturo Brunetti

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Abstract

Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (^99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(¹⁸F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

Original language	English
Pages (from-to)	325-330
Number of pages	6
Journal	Neurobiology of Aging
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0197-4580(96)00033-4
Publication status	Published - May 1996

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Keywords

brain imaging
EEG
MRI
PET
SPECT
Werner's syndrome

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

Cite this

Postiglione, A., Soricelli, A., Covelli, E. M., Iazzetta, N., Ruocco, A., Milan, G., Santoro, L., Alfano, B., & Brunetti, A. (1996). Premature aging in Werner's syndrome spares the central nervous system. Neurobiology of Aging, 17(3), 325-330. https://doi.org/10.1016/0197-4580(96)00033-4

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abstract = "Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.",

keywords = "brain imaging, EEG, MRI, PET, SPECT, Werner's syndrome",

author = "Alfredo Postiglione and Andrea Soricelli and Covelli, {Eugenio M.} and Nicolangelo Iazzetta and Antonio Ruocco and Graziella Milan and Lucio Santoro and Bruno Alfano and Arturo Brunetti",

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AU - Postiglione, Alfredo

AU - Soricelli, Andrea

AU - Covelli, Eugenio M.

AU - Iazzetta, Nicolangelo

AU - Ruocco, Antonio

AU - Milan, Graziella

AU - Santoro, Lucio

AU - Alfano, Bruno

AU - Brunetti, Arturo

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N2 - Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

AB - Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

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KW - MRI

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10.1016/0197-4580(96)00033-4