Premature aging in Werner's syndrome spares the central nervous system

Alfredo Postiglione, Andrea Soricelli, Eugenio M. Covelli, Nicolangelo Iazzetta, Antonio Ruocco, Graziella Milan, Lucio Santoro, Bruno Alfano, Arturo Brunetti

Research output: Contribution to journalArticle

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Abstract

Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNeurobiology of Aging
Volume17
Issue number3
DOIs
Publication statusPublished - May 1996

Fingerprint

Werner Syndrome
Premature Aging
Central Nervous System
Siblings
Inborn Genetic Diseases
Oximes
Magnetic Resonance Angiography
Fluorodeoxyglucose F18
Electromyography
Rare Diseases
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography
Amines
Electroencephalography
Magnetic Resonance Imaging
Brain

Keywords

  • brain imaging
  • EEG
  • MRI
  • PET
  • SPECT
  • Werner's syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Postiglione, A., Soricelli, A., Covelli, E. M., Iazzetta, N., Ruocco, A., Milan, G., ... Brunetti, A. (1996). Premature aging in Werner's syndrome spares the central nervous system. Neurobiology of Aging, 17(3), 325-330. https://doi.org/10.1016/0197-4580(96)00033-4

Premature aging in Werner's syndrome spares the central nervous system. / Postiglione, Alfredo; Soricelli, Andrea; Covelli, Eugenio M.; Iazzetta, Nicolangelo; Ruocco, Antonio; Milan, Graziella; Santoro, Lucio; Alfano, Bruno; Brunetti, Arturo.

In: Neurobiology of Aging, Vol. 17, No. 3, 05.1996, p. 325-330.

Research output: Contribution to journalArticle

Postiglione, A, Soricelli, A, Covelli, EM, Iazzetta, N, Ruocco, A, Milan, G, Santoro, L, Alfano, B & Brunetti, A 1996, 'Premature aging in Werner's syndrome spares the central nervous system', Neurobiology of Aging, vol. 17, no. 3, pp. 325-330. https://doi.org/10.1016/0197-4580(96)00033-4
Postiglione, Alfredo ; Soricelli, Andrea ; Covelli, Eugenio M. ; Iazzetta, Nicolangelo ; Ruocco, Antonio ; Milan, Graziella ; Santoro, Lucio ; Alfano, Bruno ; Brunetti, Arturo. / Premature aging in Werner's syndrome spares the central nervous system. In: Neurobiology of Aging. 1996 ; Vol. 17, No. 3. pp. 325-330.
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