Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals

Paolo Palma, Stefano Rinaldi, Nicola Cotugno, Veronica Santilli, Savita Pahwa, Paolo Rossi, Alberto Cagigi

Research output: Contribution to journalArticle

Abstract

Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.

Original languageEnglish
Pages (from-to)2083-2088
Number of pages6
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 1 2014

Keywords

  • Activation-induced deaminase (AID)
  • Aging
  • Double negative B-cells
  • Immunization
  • Immunosenescence
  • Inflammaging
  • Mature-activated B-cells
  • Predictive biomarkers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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