TY - JOUR
T1 - Premature ovarian failure
AU - Vegetti, Walter
AU - Marozzi, Anna
AU - Manfredini, Emanuela
AU - Testa, Giovanna
AU - Alagna, Federica
AU - Nicolosi, Annaelisa
AU - Caliari, Ilaria
AU - Taborelli, Monica
AU - Tibiletti, Maria Grazia
AU - Dalprà, Leda
AU - Crosignani, Pier Giorgio
PY - 2000/3/30
Y1 - 2000/3/30
N2 - Secondary amenorrhoea with elevated gonadotrophins occurring under the age of 40 (premature ovarian failure (POF)), and at the age between 41 and 44 years (early menopause (EM)), respectively, affects 1-2% and 5% of women in the general population. Objective of this study was to evaluate the prevalence of familial cases of POF and EM and to assess the clinical and genetic characteristics of these patients. One hundred and sixty women with idiopathic secondary amenorrhoea before the age of 45 and serum follicle-stimulating hormone (FSH) levels greater than or equal to 40 IU/l were included in the study. Tests performed on patients included complete medical history, pedigree's analysis, clinical pelvic examination, gonadotrophins and thyroid assessment, chromosomal analysis. The 160 patients included in the study showed idiopathic POF (n=130) or EM (n=30). Following pedigree assessment, we were able to identify an incidence of familial cases of 28.5% in the POF group (n=37) and of 50% in the EM group (n=15). POF and EM condition were often present in the same family. There were no differences between POF and EM patients and between familial and sporadic cases regarding age at menarche, personal history, gynaecological history, weight, height and diet habits. There was a statistically significant difference between sporadic and familial cases in age at POF onset: 32.0±7.3 years (12-40) compared to 35.0±5.8 (18-40), respectively (P
AB - Secondary amenorrhoea with elevated gonadotrophins occurring under the age of 40 (premature ovarian failure (POF)), and at the age between 41 and 44 years (early menopause (EM)), respectively, affects 1-2% and 5% of women in the general population. Objective of this study was to evaluate the prevalence of familial cases of POF and EM and to assess the clinical and genetic characteristics of these patients. One hundred and sixty women with idiopathic secondary amenorrhoea before the age of 45 and serum follicle-stimulating hormone (FSH) levels greater than or equal to 40 IU/l were included in the study. Tests performed on patients included complete medical history, pedigree's analysis, clinical pelvic examination, gonadotrophins and thyroid assessment, chromosomal analysis. The 160 patients included in the study showed idiopathic POF (n=130) or EM (n=30). Following pedigree assessment, we were able to identify an incidence of familial cases of 28.5% in the POF group (n=37) and of 50% in the EM group (n=15). POF and EM condition were often present in the same family. There were no differences between POF and EM patients and between familial and sporadic cases regarding age at menarche, personal history, gynaecological history, weight, height and diet habits. There was a statistically significant difference between sporadic and familial cases in age at POF onset: 32.0±7.3 years (12-40) compared to 35.0±5.8 (18-40), respectively (P
KW - Familial
KW - Genetic
KW - Idiopathic
KW - Premature ovarian failure
KW - Reproductive risk
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U2 - 10.1016/S0303-7207(99)00224-5
DO - 10.1016/S0303-7207(99)00224-5
M3 - Article
C2 - 10773392
AN - SCOPUS:0034732352
VL - 161
SP - 53
EP - 57
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -