Premature ovarian failure: Frequency and risk factors among women attending a network of menopause clinics in Italy

F. Parazzini, D. De Aloysio, P. Di Donato, N. A. Giulini, A. Bacchi Modena, G. Cicchetti, G. Comitini, G. Gentile, P. Cristiani, A. Careccia, E. Esposito, F. Gualdi, S. Golinelli, E. Berga-mini, G. Masellis, S. Rastelli, C. Gigli, A. Elia, D. Marchesoni, F. SticottiG. Del Frate, C. Zompicchiatti, L. Marino, M. R. Costa, P. Pinto, D. Dodero, A. Storace, G. Spinelli, S. Quaranta, C. M. Bossi, A. Ollago, U. Omodei, M. Vaccari, M. Luerti, F. Repetti, G. Zandonini, F. Raspagliesi, F. Dolci, G. Gambarino, B. De Pasquale, G. Polizzotti, G. Borsellino, P. Alpi-nelli, N. Natale, D. Colombo, C. Belloni, A. Viani, G. Cecchini, G. W. Vinci, B. A. Samaja, E. Pasinetti, M. Penotti, F. Ognissanti, P. Pesando, C. Malanetto, M. Gallo, G. Dolfin, P. Tartaglino, D. Mossotto, A. Pistoni, A. Tarani, P. D. Rattazzi, D. Rossaro, M. Campanella, E. Arisi, M. Gamper, D. Salvatores, E. Bocchin, G. Stellin, G. Meli, V. Azzini, F. Tirozzi, G. Buoso, R. Fraioli, V. Mar-soni, C. Cetera, R. Sposetti, E. Candiotto, R. Pignalosa, L. Del Pup, U. Bellati, C. Angeloni, M. Buonerba, S. Garzarelli, C. Santilli, M. Mucci, Q. Di Nisio, F. Cappa, I. Pierangeli, A. Cordone, L. Falasca, D. Ferrante, G. B. Serra, E. Cirese, P. A. Todaro, C. Romanini, L. Spagnuolo, A. Lanzone, C. Donadio

Research output: Contribution to journalArticle

Abstract

Objective: To determine the frequency and causes of preterm ovarian failure (menopause before 40 years of age) and early menopause (menopause between 40 and 45 years). Design: Cross sectional study. Setting: Menopause clinics in Italy. Population: Women attending menopause clinics in Italy. Methods: Between 1997 and 1999 we conducted a large cross sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms. Eligible for the study were all women aged 45-75 years consecutively observed for the first time at the participating centres on randomly selected days during the study period. Main outcome measure: Factors associated with preterm ovarian failure. Results: Out of 15,253 women aged 55 years or more with spontaneous menopause who entered the study, 269 (1.8%) reported preterm ovarian failure, and 1085 (7.1%) reported spontaneous menopause at age 40-45 years. The risk of preterm ovarian failure and of early menopause was higher in women reporting lifelong irregular menstrual cycles: in comparison with women reporting menopause at age z45 years, the OR (irregular vs regular mestrual cycles) of preterm ovarian failure was 1.3 (95% CI 1.0-1.7) and of early menopause of 1.2 (95% CI 1.0-1.5). Parous women reported less frequently preterm ovarian failure (x2 trend P <0.05) and early menopause (OR 0.8, 95% CI 0.7-1.0). No significant association emerged between risk of preterm ovarian failure or menopause at age 40 to

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume110
Issue number1
Publication statusPublished - Jan 1 2003

Fingerprint

Primary Ovarian Insufficiency
Menopause
Italy
Menstrual Cycle
Cross-Sectional Studies
Ambulatory Care Facilities

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Parazzini, F., De Aloysio, D., Di Donato, P., Giulini, N. A., Bacchi Modena, A., Cicchetti, G., ... Donadio, C. (2003). Premature ovarian failure: Frequency and risk factors among women attending a network of menopause clinics in Italy. BJOG: An International Journal of Obstetrics and Gynaecology, 110(1), 59-63.

Premature ovarian failure : Frequency and risk factors among women attending a network of menopause clinics in Italy. / Parazzini, F.; De Aloysio, D.; Di Donato, P.; Giulini, N. A.; Bacchi Modena, A.; Cicchetti, G.; Comitini, G.; Gentile, G.; Cristiani, P.; Careccia, A.; Esposito, E.; Gualdi, F.; Golinelli, S.; Berga-mini, E.; Masellis, G.; Rastelli, S.; Gigli, C.; Elia, A.; Marchesoni, D.; Sticotti, F.; Del Frate, G.; Zompicchiatti, C.; Marino, L.; Costa, M. R.; Pinto, P.; Dodero, D.; Storace, A.; Spinelli, G.; Quaranta, S.; Bossi, C. M.; Ollago, A.; Omodei, U.; Vaccari, M.; Luerti, M.; Repetti, F.; Zandonini, G.; Raspagliesi, F.; Dolci, F.; Gambarino, G.; De Pasquale, B.; Polizzotti, G.; Borsellino, G.; Alpi-nelli, P.; Natale, N.; Colombo, D.; Belloni, C.; Viani, A.; Cecchini, G.; Vinci, G. W.; Samaja, B. A.; Pasinetti, E.; Penotti, M.; Ognissanti, F.; Pesando, P.; Malanetto, C.; Gallo, M.; Dolfin, G.; Tartaglino, P.; Mossotto, D.; Pistoni, A.; Tarani, A.; Rattazzi, P. D.; Rossaro, D.; Campanella, M.; Arisi, E.; Gamper, M.; Salvatores, D.; Bocchin, E.; Stellin, G.; Meli, G.; Azzini, V.; Tirozzi, F.; Buoso, G.; Fraioli, R.; Mar-soni, V.; Cetera, C.; Sposetti, R.; Candiotto, E.; Pignalosa, R.; Del Pup, L.; Bellati, U.; Angeloni, C.; Buonerba, M.; Garzarelli, S.; Santilli, C.; Mucci, M.; Di Nisio, Q.; Cappa, F.; Pierangeli, I.; Cordone, A.; Falasca, L.; Ferrante, D.; Serra, G. B.; Cirese, E.; Todaro, P. A.; Romanini, C.; Spagnuolo, L.; Lanzone, A.; Donadio, C.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 110, No. 1, 01.01.2003, p. 59-63.

Research output: Contribution to journalArticle

Parazzini, F, De Aloysio, D, Di Donato, P, Giulini, NA, Bacchi Modena, A, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gualdi, F, Golinelli, S, Berga-mini, E, Masellis, G, Rastelli, S, Gigli, C, Elia, A, Marchesoni, D, Sticotti, F, Del Frate, G, Zompicchiatti, C, Marino, L, Costa, MR, Pinto, P, Dodero, D, Storace, A, Spinelli, G, Quaranta, S, Bossi, CM, Ollago, A, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Gambarino, G, De Pasquale, B, Polizzotti, G, Borsellino, G, Alpi-nelli, P, Natale, N, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Vinci, GW, Samaja, BA, Pasinetti, E, Penotti, M, Ognissanti, F, Pesando, P, Malanetto, C, Gallo, M, Dolfin, G, Tartaglino, P, Mossotto, D, Pistoni, A, Tarani, A, Rattazzi, PD, Rossaro, D, Campanella, M, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Mar-soni, V, Cetera, C, Sposetti, R, Candiotto, E, Pignalosa, R, Del Pup, L, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Cappa, F, Pierangeli, I, Cordone, A, Falasca, L, Ferrante, D, Serra, GB, Cirese, E, Todaro, PA, Romanini, C, Spagnuolo, L, Lanzone, A & Donadio, C 2003, 'Premature ovarian failure: Frequency and risk factors among women attending a network of menopause clinics in Italy', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 110, no. 1, pp. 59-63.
Parazzini, F. ; De Aloysio, D. ; Di Donato, P. ; Giulini, N. A. ; Bacchi Modena, A. ; Cicchetti, G. ; Comitini, G. ; Gentile, G. ; Cristiani, P. ; Careccia, A. ; Esposito, E. ; Gualdi, F. ; Golinelli, S. ; Berga-mini, E. ; Masellis, G. ; Rastelli, S. ; Gigli, C. ; Elia, A. ; Marchesoni, D. ; Sticotti, F. ; Del Frate, G. ; Zompicchiatti, C. ; Marino, L. ; Costa, M. R. ; Pinto, P. ; Dodero, D. ; Storace, A. ; Spinelli, G. ; Quaranta, S. ; Bossi, C. M. ; Ollago, A. ; Omodei, U. ; Vaccari, M. ; Luerti, M. ; Repetti, F. ; Zandonini, G. ; Raspagliesi, F. ; Dolci, F. ; Gambarino, G. ; De Pasquale, B. ; Polizzotti, G. ; Borsellino, G. ; Alpi-nelli, P. ; Natale, N. ; Colombo, D. ; Belloni, C. ; Viani, A. ; Cecchini, G. ; Vinci, G. W. ; Samaja, B. A. ; Pasinetti, E. ; Penotti, M. ; Ognissanti, F. ; Pesando, P. ; Malanetto, C. ; Gallo, M. ; Dolfin, G. ; Tartaglino, P. ; Mossotto, D. ; Pistoni, A. ; Tarani, A. ; Rattazzi, P. D. ; Rossaro, D. ; Campanella, M. ; Arisi, E. ; Gamper, M. ; Salvatores, D. ; Bocchin, E. ; Stellin, G. ; Meli, G. ; Azzini, V. ; Tirozzi, F. ; Buoso, G. ; Fraioli, R. ; Mar-soni, V. ; Cetera, C. ; Sposetti, R. ; Candiotto, E. ; Pignalosa, R. ; Del Pup, L. ; Bellati, U. ; Angeloni, C. ; Buonerba, M. ; Garzarelli, S. ; Santilli, C. ; Mucci, M. ; Di Nisio, Q. ; Cappa, F. ; Pierangeli, I. ; Cordone, A. ; Falasca, L. ; Ferrante, D. ; Serra, G. B. ; Cirese, E. ; Todaro, P. A. ; Romanini, C. ; Spagnuolo, L. ; Lanzone, A. ; Donadio, C. / Premature ovarian failure : Frequency and risk factors among women attending a network of menopause clinics in Italy. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2003 ; Vol. 110, No. 1. pp. 59-63.
@article{1f67a54ee51d4eecb0e03d4bef91e7eb,
title = "Premature ovarian failure: Frequency and risk factors among women attending a network of menopause clinics in Italy",
abstract = "Objective: To determine the frequency and causes of preterm ovarian failure (menopause before 40 years of age) and early menopause (menopause between 40 and 45 years). Design: Cross sectional study. Setting: Menopause clinics in Italy. Population: Women attending menopause clinics in Italy. Methods: Between 1997 and 1999 we conducted a large cross sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms. Eligible for the study were all women aged 45-75 years consecutively observed for the first time at the participating centres on randomly selected days during the study period. Main outcome measure: Factors associated with preterm ovarian failure. Results: Out of 15,253 women aged 55 years or more with spontaneous menopause who entered the study, 269 (1.8{\%}) reported preterm ovarian failure, and 1085 (7.1{\%}) reported spontaneous menopause at age 40-45 years. The risk of preterm ovarian failure and of early menopause was higher in women reporting lifelong irregular menstrual cycles: in comparison with women reporting menopause at age z45 years, the OR (irregular vs regular mestrual cycles) of preterm ovarian failure was 1.3 (95{\%} CI 1.0-1.7) and of early menopause of 1.2 (95{\%} CI 1.0-1.5). Parous women reported less frequently preterm ovarian failure (x2 trend P <0.05) and early menopause (OR 0.8, 95{\%} CI 0.7-1.0). No significant association emerged between risk of preterm ovarian failure or menopause at age 40 to",
author = "F. Parazzini and {De Aloysio}, D. and {Di Donato}, P. and Giulini, {N. A.} and {Bacchi Modena}, A. and G. Cicchetti and G. Comitini and G. Gentile and P. Cristiani and A. Careccia and E. Esposito and F. Gualdi and S. Golinelli and E. Berga-mini and G. Masellis and S. Rastelli and C. Gigli and A. Elia and D. Marchesoni and F. Sticotti and {Del Frate}, G. and C. Zompicchiatti and L. Marino and Costa, {M. R.} and P. Pinto and D. Dodero and A. Storace and G. Spinelli and S. Quaranta and Bossi, {C. M.} and A. Ollago and U. Omodei and M. Vaccari and M. Luerti and F. Repetti and G. Zandonini and F. Raspagliesi and F. Dolci and G. Gambarino and {De Pasquale}, B. and G. Polizzotti and G. Borsellino and P. Alpi-nelli and N. Natale and D. Colombo and C. Belloni and A. Viani and G. Cecchini and Vinci, {G. W.} and Samaja, {B. A.} and E. Pasinetti and M. Penotti and F. Ognissanti and P. Pesando and C. Malanetto and M. Gallo and G. Dolfin and P. Tartaglino and D. Mossotto and A. Pistoni and A. Tarani and Rattazzi, {P. D.} and D. Rossaro and M. Campanella and E. Arisi and M. Gamper and D. Salvatores and E. Bocchin and G. Stellin and G. Meli and V. Azzini and F. Tirozzi and G. Buoso and R. Fraioli and V. Mar-soni and C. Cetera and R. Sposetti and E. Candiotto and R. Pignalosa and {Del Pup}, L. and U. Bellati and C. Angeloni and M. Buonerba and S. Garzarelli and C. Santilli and M. Mucci and {Di Nisio}, Q. and F. Cappa and I. Pierangeli and A. Cordone and L. Falasca and D. Ferrante and Serra, {G. B.} and E. Cirese and Todaro, {P. A.} and C. Romanini and L. Spagnuolo and A. Lanzone and C. Donadio",
year = "2003",
month = "1",
day = "1",
language = "English",
volume = "110",
pages = "59--63",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Premature ovarian failure

T2 - Frequency and risk factors among women attending a network of menopause clinics in Italy

AU - Parazzini, F.

AU - De Aloysio, D.

AU - Di Donato, P.

AU - Giulini, N. A.

AU - Bacchi Modena, A.

AU - Cicchetti, G.

AU - Comitini, G.

AU - Gentile, G.

AU - Cristiani, P.

AU - Careccia, A.

AU - Esposito, E.

AU - Gualdi, F.

AU - Golinelli, S.

AU - Berga-mini, E.

AU - Masellis, G.

AU - Rastelli, S.

AU - Gigli, C.

AU - Elia, A.

AU - Marchesoni, D.

AU - Sticotti, F.

AU - Del Frate, G.

AU - Zompicchiatti, C.

AU - Marino, L.

AU - Costa, M. R.

AU - Pinto, P.

AU - Dodero, D.

AU - Storace, A.

AU - Spinelli, G.

AU - Quaranta, S.

AU - Bossi, C. M.

AU - Ollago, A.

AU - Omodei, U.

AU - Vaccari, M.

AU - Luerti, M.

AU - Repetti, F.

AU - Zandonini, G.

AU - Raspagliesi, F.

AU - Dolci, F.

AU - Gambarino, G.

AU - De Pasquale, B.

AU - Polizzotti, G.

AU - Borsellino, G.

AU - Alpi-nelli, P.

AU - Natale, N.

AU - Colombo, D.

AU - Belloni, C.

AU - Viani, A.

AU - Cecchini, G.

AU - Vinci, G. W.

AU - Samaja, B. A.

AU - Pasinetti, E.

AU - Penotti, M.

AU - Ognissanti, F.

AU - Pesando, P.

AU - Malanetto, C.

AU - Gallo, M.

AU - Dolfin, G.

AU - Tartaglino, P.

AU - Mossotto, D.

AU - Pistoni, A.

AU - Tarani, A.

AU - Rattazzi, P. D.

AU - Rossaro, D.

AU - Campanella, M.

AU - Arisi, E.

AU - Gamper, M.

AU - Salvatores, D.

AU - Bocchin, E.

AU - Stellin, G.

AU - Meli, G.

AU - Azzini, V.

AU - Tirozzi, F.

AU - Buoso, G.

AU - Fraioli, R.

AU - Mar-soni, V.

AU - Cetera, C.

AU - Sposetti, R.

AU - Candiotto, E.

AU - Pignalosa, R.

AU - Del Pup, L.

AU - Bellati, U.

AU - Angeloni, C.

AU - Buonerba, M.

AU - Garzarelli, S.

AU - Santilli, C.

AU - Mucci, M.

AU - Di Nisio, Q.

AU - Cappa, F.

AU - Pierangeli, I.

AU - Cordone, A.

AU - Falasca, L.

AU - Ferrante, D.

AU - Serra, G. B.

AU - Cirese, E.

AU - Todaro, P. A.

AU - Romanini, C.

AU - Spagnuolo, L.

AU - Lanzone, A.

AU - Donadio, C.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Objective: To determine the frequency and causes of preterm ovarian failure (menopause before 40 years of age) and early menopause (menopause between 40 and 45 years). Design: Cross sectional study. Setting: Menopause clinics in Italy. Population: Women attending menopause clinics in Italy. Methods: Between 1997 and 1999 we conducted a large cross sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms. Eligible for the study were all women aged 45-75 years consecutively observed for the first time at the participating centres on randomly selected days during the study period. Main outcome measure: Factors associated with preterm ovarian failure. Results: Out of 15,253 women aged 55 years or more with spontaneous menopause who entered the study, 269 (1.8%) reported preterm ovarian failure, and 1085 (7.1%) reported spontaneous menopause at age 40-45 years. The risk of preterm ovarian failure and of early menopause was higher in women reporting lifelong irregular menstrual cycles: in comparison with women reporting menopause at age z45 years, the OR (irregular vs regular mestrual cycles) of preterm ovarian failure was 1.3 (95% CI 1.0-1.7) and of early menopause of 1.2 (95% CI 1.0-1.5). Parous women reported less frequently preterm ovarian failure (x2 trend P <0.05) and early menopause (OR 0.8, 95% CI 0.7-1.0). No significant association emerged between risk of preterm ovarian failure or menopause at age 40 to

AB - Objective: To determine the frequency and causes of preterm ovarian failure (menopause before 40 years of age) and early menopause (menopause between 40 and 45 years). Design: Cross sectional study. Setting: Menopause clinics in Italy. Population: Women attending menopause clinics in Italy. Methods: Between 1997 and 1999 we conducted a large cross sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in Italy for general counselling about menopause or treatment of menopausal symptoms. Eligible for the study were all women aged 45-75 years consecutively observed for the first time at the participating centres on randomly selected days during the study period. Main outcome measure: Factors associated with preterm ovarian failure. Results: Out of 15,253 women aged 55 years or more with spontaneous menopause who entered the study, 269 (1.8%) reported preterm ovarian failure, and 1085 (7.1%) reported spontaneous menopause at age 40-45 years. The risk of preterm ovarian failure and of early menopause was higher in women reporting lifelong irregular menstrual cycles: in comparison with women reporting menopause at age z45 years, the OR (irregular vs regular mestrual cycles) of preterm ovarian failure was 1.3 (95% CI 1.0-1.7) and of early menopause of 1.2 (95% CI 1.0-1.5). Parous women reported less frequently preterm ovarian failure (x2 trend P <0.05) and early menopause (OR 0.8, 95% CI 0.7-1.0). No significant association emerged between risk of preterm ovarian failure or menopause at age 40 to

UR - http://www.scopus.com/inward/record.url?scp=0037221590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037221590&partnerID=8YFLogxK

M3 - Article

C2 - 12504937

AN - SCOPUS:0037221590

VL - 110

SP - 59

EP - 63

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 1

ER -