Premature ovarian failure in suspected Whipple's disease

Stefano Ferrari, Francesca Di Puppo, Paola Persico, Augusto Ferrari

Research output: Contribution to journalArticle

Abstract

Introduction: Whipple's disease is a relapsing systemic infectious disease probably caused by the Gram-positive bacillus Tropheryma whippelii. The diagnosis can be established based on the characteristic histopathological features found in the affected organ (foamy macrophages with a coarsely granular cytoplasm, which stains with PAS, and by means of polymerase chain reaction (PCR) technology). Case Report: We report a case of a 23-year-old woman affected by suspected Whipple's disease. She presented encephalopathy and neuropathy with inveterate hyperpyrexia and alteration of the hypothalamic-pituitary-ovary axe. She was amenorrhoic because of an hypergonadotropic hypogonadism. Discussion: This hypogonadism is possibly due to follicular depletion caused by inveterate hyperpyrexia or T. whipplii localization.

Original languageEnglish
JournalFertility and Sterility
Volume88
Issue number6
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Whipple Disease
Primary Ovarian Insufficiency
Hypogonadism
Tropheryma
Brain Diseases
Bacillus
Communicable Diseases
Ovary
Cytoplasm
Coloring Agents
Macrophages
Technology
Polymerase Chain Reaction

Keywords

  • hypergonadotropic hypogonadism
  • Hyperthermia
  • premature ovarian failure
  • Whipple's disease

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Premature ovarian failure in suspected Whipple's disease. / Ferrari, Stefano; Di Puppo, Francesca; Persico, Paola; Ferrari, Augusto.

In: Fertility and Sterility, Vol. 88, No. 6, 12.2007.

Research output: Contribution to journalArticle

Ferrari, Stefano ; Di Puppo, Francesca ; Persico, Paola ; Ferrari, Augusto. / Premature ovarian failure in suspected Whipple's disease. In: Fertility and Sterility. 2007 ; Vol. 88, No. 6.
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